Recruited STAT5 is phosphorylated

Stable Identifier
R-HSA-452097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruited STAT5 is phosphorylated
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STAT5 alpha and beta are recruited to the receptor complex and phosphorylated. JAK3 is believed to be responsible for the tyrosine phosphorylation of STAT5 in response to IL-2; it is not clear whether JAK1 is also involved (Lin & Leonard, 2000). Tyr-694 of STAT5a and Tyr-699 of STAT5b are required for IL-2 induced STAT5 activation (Lin et al. 1996). STAT5a and STAT5b are also known to be serine phosphorylated in lymphocytes activated by IL-2 but the funtion of this is unclear (Xue et al. 2002).
Literature References
PubMed ID Title Journal Year
7568001 Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15

Ortaldo, JR, Finbloom, DS, Shibuya, K, Kaplan, D, Giri, JD, Bacon, CM, Chen, YQ, Gupta, S, Johnston, JA, Rees, RC

Proc Natl Acad Sci U S A 1995
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane]

Physical Entity
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Recruited STAT5 is phosphorylated (Bos taurus)
Recruited STAT5 is phosphorylated (Canis familiaris)
Recruited STAT5 is phosphorylated (Mus musculus)
Recruited STAT5 is phosphorylated (Rattus norvegicus)
Recruited STAT5 is phosphorylated (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Dooms, H  (2011-03-17)
Villarino, A  (2011-02-11)
Created
Jupe, S  (2010-01-15)
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