arginine + H2O => ornithine + urea [ARG2]

Stable Identifier
R-HSA-452036
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arginase 2 (ARG2) trimer catalyzes the hydrolysis of arginine to form urea and ornithine (Cama et al. 2003). ARG2 is localized to the mitochondrion (Gotoh ea 1996). The enzyme is expressed in many tissues in addition to liver and while its function appears to mitigate the effects of ARG1 deficiency on urea synthesis, its normal physiological roles have not been fully defined (Iyer et al. 1998).

Literature References
PubMed ID Title Journal Year
8898077 Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line

Gotoh, T, Sonoki, T, Nagasaki, A, Terada, K, Takiguchi, M, Mori, M

FEBS Lett 1996
9686347 The human arginases and arginase deficiency

Iyer, RK, Jenkinson, CP, Vockley, JG, Kern, RM, Grody, WW, Cederbaum, SD

J Inherit Metab Dis 1998
12859189 Human arginase II: crystal structure and physiological role in male and female sexual arousal

Cama, E, Colleluori, DM, Emig, FA, Shin, H, Kim, SW, Kim, NN, Traish, AM, Ash, DE, Christianson, DW

Biochemistry 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arginase activity of ARG2 trimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created