Reactome | Interleukin-2 family signaling

Interleukin-2 family signaling

Stable Identifier

R-HSA-451927

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The interleukin-2 family (also called the common gamma chain cytokine family) consists of interleukin (IL)2, IL9, IL15 and IL21. Although sometimes considered to be within this family, the IL4 and IL7 receptors can form complexes with other receptor chains and are represented separately in Reactome. Receptors of this family associate with JAK1 and JAK3, primarily activating STAT5, although certain family members can also activate STAT1, STAT3 or STAT6.

Literature References

PubMed ID	Title	Journal	Year
19543225	New insights into the regulation of T cells by gamma(c) family cytokines Rochman, Y, Spolski, R, Leonard, WJ	Nat Rev Immunol	2009
18817510	Structural biology of shared cytokine receptors Wang, X, Lupardus, P, Laporte, SL, Garcia, KC	Annu Rev Immunol	2009
25200249	The IL-2 cytokine family in cancer immunotherapy Sim, GC, Radvanyi, L	Cytokine Growth Factor Rev.	2014