Activation of kainate receptors upon glutamate binding

Stable Identifier
R-HSA-451326
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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Activation of kainate receptors upon glutamate binding
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Kainate receptors are found both in the presynaptc terminals and the postsynaptic neurons.
Kainate receptor activation could lead to either ionotropic activity (influx of Ca2+ or Na+ and K+) in the postsynaptic neuron or coupling of the receptor with G proteins in the presynaptic and the postsynaptic neurons.
Kainate receptors are tetramers made from subunits GRIK1-5 or GluR5-7 and KA1-2. Activation of kainate receptors made from GRIK1 or KA2 release Ca2+ from the intracellular stores in a G protein-dependent manner. The G protein involved in this process is sensitive to pertussis toxin.
Literature References
PubMed ID Title Journal Year
18793656 Kainate receptors: pharmacology, function and therapeutic potential

Jane, DE, Lodge, D, Collingridge, GL

Neuropharmacology 2009
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
Activation of kainate receptors upon glutamate binding (Bos taurus)
Activation of kainate receptors upon glutamate binding (Caenorhabditis elegans)
Activation of kainate receptors upon glutamate binding (Canis familiaris)
Activation of kainate receptors upon glutamate binding (Drosophila melanogaster)
Activation of kainate receptors upon glutamate binding (Gallus gallus)
Activation of kainate receptors upon glutamate binding (Mus musculus)
Activation of kainate receptors upon glutamate binding (Rattus norvegicus)
Activation of kainate receptors upon glutamate binding (Sus scrofa)
Activation of kainate receptors upon glutamate binding (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-01-15)
Reviewed
Tukey, D  (2009-11-18)
Created
Mahajan, SS  (2010-01-05)
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