Reactome | Microtubule-independent trafficking of connexons to the plasma membrane

Microtubule-independent trafficking of connexons to the plasma membrane

Stable Identifier

R-HSA-451056

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction assembly (Homo sapiens)
        
        Transport of connexons to the plasma membrane (Homo sapiens)
        
        Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)

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Microtubule-independent trafficking of connexons to the plasma membrane

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Connexons may also traffic using a microtubule-independent mechanism. A few studies suggest that rough ER membranes can directly transfer connexons to the plasma membrane (Martin et al. 2001; Bloom and Goldstein 1998). Other cytoskeletal components, such as actin filaments, might be involved in the delivery of connexons to gap junction plaques (Thomas et al. 2001; Gilleron et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
11719551	Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels Martin, PE, Errington, RJ, Ahmad, S, Blundell, G, Evans, WH	J Cell Sci	2001