Reactome | (S)-Malate <=> Fumarate + H2O

(S)-Malate <=> Fumarate + H2O

Stable Identifier

R-HSA-451033

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Literature References

PubMed ID	Title	Journal	Year
8200987	Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency Bourgeron, T, Chretien, D, Poggi-Bach, J, Doonan, S, Rabier, D, Letouzé, P, Munnich, A, Rötig, A, Landrieu, P, Rustin, P	J Clin Invest	1994