(S)-Malate <=> Fumarate + H2O

Stable Identifier
R-HSA-451033
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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(S)-Malate <=> Fumarate + H2O
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Mitochondrial fumarate hydratase catalyzes the reversible reaction of malate to form fumarate and water (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Literature References
PubMed ID Title Journal Year
8200987 Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency

Chretien, D, Landrieu, P, Doonan, S, Bourgeron, T, Rabier, D, Poggi-Bach, J, Rötig, A, Letouzé, P, Munnich, A, Rustin, P

J Clin Invest 1994
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Event Information
Reverse Reaction
Fumarate + H2O <=> (S)-Malate (Homo sapiens)
Catalyst Activity

fumarate hydratase activity of FH tetramer [mitochondrial matrix]

Physical Entity
FH tetramer [mitochondrial matrix] (Homo sapiens)
Activity
fumarate hydratase activity (GO:0004333)
Orthologous Events
(S)-Malate <=> Fumarate + H2O (Bos taurus)
(S)-Malate <=> Fumarate + H2O (Caenorhabditis elegans)
(S)-Malate <=> Fumarate + H2O (Canis familiaris)
(S)-Malate <=> Fumarate + H2O (Danio rerio)
(S)-Malate <=> Fumarate + H2O (Dictyostelium discoideum)
(S)-Malate <=> Fumarate + H2O (Drosophila melanogaster)
(S)-Malate <=> Fumarate + H2O (Gallus gallus)
(S)-Malate <=> Fumarate + H2O (Mus musculus)
(S)-Malate <=> Fumarate + H2O (Rattus norvegicus)
(S)-Malate <=> Fumarate + H2O (Saccharomyces cerevisiae)
(S)-Malate <=> Fumarate + H2O (Schizosaccharomyces pombe)
(S)-Malate <=> Fumarate + H2O (Sus scrofa)
(S)-Malate <=> Fumarate + H2O (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-12-26)
Created
D'Eustachio, P  (2009-12-26)
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