hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.

Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6.

Literature References
PubMed ID Title Journal Year
19264966 Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

Peggie, M, Campbell, DG, Carrick, E, Smith, H, Vandermoere, F, Cohen, P

Proc Natl Acad Sci U S A 2009
12860405 Characterization of Pellino2, a substrate of IRAK1 and IRAK4

Wesche, H, Strelow, A, Kollewe, C

FEBS Lett 2003
Catalyst Activity

protein serine/threonine kinase activity of hp-IRAK1:Pellino, IRAK4:Pellino [cytosol]

Orthologous Events
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