Reactome | hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2

hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2

Stable Identifier

R-HSA-450827

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2

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IRAK1 and 4 can phosphorylate Pellino-1 and -2 and probably -3. Phosphorylation enhances the E3 ligase activity of Pellino-1 in conjunction with several different E2-conjugating enzymes (Ubc13-Uev1a, UbcH4, or UbcH5a/5b). Phosphorylation at any of several different sites or a combination of other sites leads to full activation of Pellino-1 E3 ubiquitin ligase activity.

Though not shown here, the current models of IRAK1 involvement suggest it is part of a complex that includes TRAF6.

Literature References

PubMed ID	Title	Journal	Year
19264966	Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4 Smith, H, Peggie, M, Campbell, DG, Vandermoere, F, Carrick, E, Cohen, P	Proc Natl Acad Sci U S A	2009
12860405	Characterization of Pellino2, a substrate of IRAK1 and IRAK4 Strelow, A, Kollewe, C, Wesche, H	FEBS Lett	2003