Reactome | PKM-2 [cytosol]

PKM-2 [cytosol]

Stable Identifier

R-HSA-450658

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PKM isozyme M1, pyruvate kinase, M1 isozyme , PKM isoform 2

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - PKM dephosphorylates PEP to PYR (Homo sapiens)
      - pyruvate kinase tetramer [cytosol] (Homo sapiens)
        
        pyruvate kinase M1 complex [cytosol] (Homo sapiens)
        
        PKM-2 [cytosol] (Homo sapiens)
- Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Glycolysis (Homo sapiens)
      - PKM dephosphorylates PEP to PYR (Homo sapiens)
        
        pyruvate kinase tetramer [cytosol] (Homo sapiens)
        
        pyruvate kinase M1 complex [cytosol] (Homo sapiens)
        
        PKM-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14618-2 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Participates

as a component of

pyruvate kinase M1 complex [cytosol] (Homo sapiens)

Inferred To

Pkml1 [cytosol] (Rattus norvegicus)

pyk-2 [cytosol] (Caenorhabditis elegans)

Dmel\CG12229 [cytosol] (Drosophila melanogaster)

pkma [cytosol] (Danio rerio)

Dmel\CG7069 [cytosol] (Drosophila melanogaster)

Dmel\CG11249 [cytosol] (Drosophila melanogaster)

Dmel\CG7362 [cytosol] (Drosophila melanogaster)

pkm [cytosol] (Xenopus tropicalis)

PKM-2 [cytosol] (Dictyostelium discoideum)

PKM-2 [cytosol] (Drosophila melanogaster)

PKM-2 [cytosol] (Gallus gallus)

PKM-2 [cytosol] (Mus musculus)

PKM-2 [cytosol] (Plasmodium falciparum)

PKM-2 [cytosol] (Saccharomyces cerevisiae)

PKM-2 [cytosol] (Schizosaccharomyces pombe)

Dmel\CG2964 [cytosol] (Drosophila melanogaster)

PKM [cytosol] (Bos taurus)

PKM [cytosol] (Sus scrofa)

pklr [cytosol] (Danio rerio)

Homologues of PKM-2 [cytosol] (Caenorhabditis elegans)

Homologues of PKM-2 [cytosol] (Danio rerio)

Homologues of PKM-2 [cytosol] (Drosophila melanogaster)

Homologues of PKM-2 [cytosol] (Plasmodium falciparum)

Homologues of PKM-2 [cytosol] (Saccharomyces cerevisiae)

pyk-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_872270.1, NP_002645.3, XP_016877802.1, NP_872271.1, NP_001193728.1, NP_001193727.1, NP_001193726.1, XP_005254502.1, NP_001303247.1, NP_001193725.1

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ENSEMBL

ENSP00000320171, ENSP00000334983, ENSP00000456970, ENST00000335181, ENST00000319622, ENSG00000067225, ENST00000568459

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

GlyGen

P14618

PDB

6V74, 3SRH, 3ME3, 4FXJ, 6WP3, 8HMR, 3SRF, 4QG9, 3H6O, 4B2D, 6V75, 4YJ5, 6JFB, 6WP5, 4RPP, 3GQY, 3BJF, 6NUB, 7L21, 1ZJH, 6TTF, 3G2G, 6TTQ, 6TTH, 6B6U, 3SRD, 8HMU, 6GG5, 6WP4, 4QG8, 4FXF, 8HMQ, 8HMS, 1T5A, 4G1N, 6GG6, 6V76, 6WP6, 4WJ8, 4JPG, 8HGF, 3U2Z, 3GR4, 5X0I, 3BJT, 6NU5, 5X1V, 5X1W, 6GG3, 6NU1, 6TTI, 4QGC, 4QG6, 6GG4, 8G2E

ZINC - Metabolites

KPYM_HUMAN

HPA

ENSG00000067225-PKM

GeneCards

PKM

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.524	4
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3

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