Reactome | p-S193-KSRP binds 14-3-3zeta in the nucleus

p-S193-KSRP binds 14-3-3zeta in the nucleus

Stable Identifier

R-HSA-450620

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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p-S193-KSRP binds 14-3-3zeta in the nucleus

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KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which impairs the ability of KSRP to destabilize RNA. Thus the RNAs become stabilized. KSRP is able to shuttle between the nucleus and the cytoplasm. 14-3-3zeta is nucleoplasmic. Binding of KSRP to 14-3-3zeta causes KSRP to be retained in the nucleus.

Literature References

PubMed ID	Title	Journal	Year
19198587	Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding Briata, P, Martin, S, Ramos, A, Frenkiel, TA, Garcia-Mayoral, M, Diaz-Moreno, I, Gherzi, R, Hollingworth, D, Kelly, G, Howell, S	Nat Struct Mol Biol	2009