p-S193-KSRP binds 14-3-3zeta in the nucleus

Stable Identifier
R-HSA-450620
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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p-S193-KSRP binds 14-3-3zeta in the nucleus
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KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which impairs the ability of KSRP to destabilize RNA. Thus the RNAs become stabilized. KSRP is able to shuttle between the nucleus and the cytoplasm. 14-3-3zeta is nucleoplasmic. Binding of KSRP to 14-3-3zeta causes KSRP to be retained in the nucleus.

Literature References
PubMed ID Title Journal Year
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Diaz-Moreno, I, Hollingworth, D, Frenkiel, TA, Kelly, G, Martin, S, Howell, S, Garcia-Mayoral, M, Gherzi, R, Briata, P, Ramos, A

Nat Struct Mol Biol 2009
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Orthologous Events
p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Danio rerio)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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