p-S193-KSRP binds 14-3-3zeta in the nucleus

Stable Identifier
R-HSA-450620
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S193-KSRP binds 14-3-3zeta in the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which impairs the ability of KSRP to destabilize RNA. Thus the RNAs become stabilized. KSRP is able to shuttle between the nucleus and the cytoplasm. 14-3-3zeta is nucleoplasmic. Binding of KSRP to 14-3-3zeta causes KSRP to be retained in the nucleus.

Literature References
PubMed ID Title Journal Year
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Diaz-Moreno, I, Hollingworth, D, Frenkiel, TA, Kelly, G, Martin, S, Howell, S, Garcia-Mayoral, M, Gherzi, R, Briata, P, Ramos, A

Nat Struct Mol Biol 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
p-S193-KSRP binds 14-3-3zeta in the nucleus (Bos taurus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Drosophila melanogaster)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Mus musculus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Rattus norvegicus)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)
p-S193-KSRP binds 14-3-3zeta in the nucleus (Xenopus tropicalis)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
Cite Us!