Reactome | HuR:mRNA complex translocates from the nucleus to the cytosol

HuR:mRNA complex translocates from the nucleus to the cytosol

Stable Identifier

R-HSA-450595

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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HuR:mRNA complex translocates from the nucleus to the cytosol

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mRNA bound to HuR is exported from the nucleus by a mechanism that requires the shuttle protein APRIL but not pp32. Phosphorylation of APRIL determines its subcellular localization: APRIL phosphorylated at threonine244 is found in both the nucleus and cytoplasm while APRIL that is not phosphorylated at threonine244 is cytoplasmic.
HuR bound to mRNAs in the cytoplasm acts to stabilize the mRNAs by an unknown mechanism.

Literature References

PubMed ID	Title	Journal	Year
19130553	Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression Grüttner, C, Pieper, D, Hauber, J, Chemnitz, J	Eur J Immunol	2009
17178712	Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression Heukeshoven, J, Stocking, C, Grüttner, C, Hauber, J, Hauber, I, Kehlenbach, RH, Chemnitz, J, Fries, B	J Biol Chem	2007
15257295	Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs Gorospe, M, Yang, X, Mazan-Mamczarz, K, Lal, A, Kawai, T, Martindale, JL	EMBO J	2004