HuR:mRNA complex translocates from the nucleus to the cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
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mRNA bound to HuR is exported from the nucleus by a mechanism that requires the shuttle protein APRIL but not pp32. Phosphorylation of APRIL determines its subcellular localization: APRIL phosphorylated at threonine244 is found in both the nucleus and cytoplasm while APRIL that is not phosphorylated at threonine244 is cytoplasmic.
HuR bound to mRNAs in the cytoplasm acts to stabilize the mRNAs by an unknown mechanism.

Literature References
PubMed ID Title Journal Year
19130553 Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression

Grüttner, C, Pieper, D, Hauber, J, Chemnitz, J

Eur J Immunol 2009
17178712 Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression

Heukeshoven, J, Stocking, C, Grüttner, C, Hauber, J, Hauber, I, Kehlenbach, RH, Chemnitz, J, Fries, B

J Biol Chem 2007
15257295 Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Gorospe, M, Yang, X, Mazan-Mamczarz, K, Lal, A, Kawai, T, Martindale, JL

EMBO J 2004
Orthologous Events
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