KSRP binds AU-rich element in 3' UTR of mRNA

Stable Identifier
R-HSA-450592
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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KSRP (KHSRP) binds AU-rich regions of target RNAs via its four K-homology (KH) domains.

Literature References
PubMed ID Title Journal Year
15514971 IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR

Suswam, EA, Nabors, LB, Huang, Y, Yang, X, King, PH

Int J Cancer 2005
19141871 Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements

Li, H, Chen, W, Zhou, Y, Abidi, P, Sharpe, O, Robinson, WH, Kraemer, FB, Liu, J

J Lipid Res 2009
19854161 Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes

Schmidt, N, Pautz, A, Art, J, Rauschkolb, P, Jung, M, Erkel, G, Goldring, MB, Kleinert, H

Biochem Pharmacol 2010
18684992 The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets

Garcia-Mayoral, MF, Diaz-Moreno, I, Hollingworth, D, Ramos, A

Nucleic Acids Res 2008
17177604 The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

Gherzi, R, Trabucchi, M, Ponassi, M, Ruggiero, T, Corte, G, Moroni, C, Chen, CY, Khabar, KS, Andersen, JS, Briata, P

PLoS Biol 2006
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