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HSPB1 [cytosol]
Stable Identifier
R-HSA-450563
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSP27, Heat shock protein beta-1, HSPB1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q02790 FKBP4
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
HSPB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)
HSPB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04792 HSBP1
Gene Names
HSBP1, HSPB1, HSP27, HSP28
Chain
chain:1-205
Reference Genes
BioGPS Gene:3315 HSBP1
COSMIC (genes):HSBP1 HSBP1
COSMIC (genes):HSPB1 HSBP1
CTD Gene:3315 HSBP1
dbSNP Gene:3315 HSBP1
ENSEMBL:ENSG00000106211 HSBP1
HGNC:5246 HSBP1
KEGG:hsa:3315 HSBP1
Monarch:3315 HSBP1
NCBI Gene:3315 HSBP1
OMIM:602195 HSBP1
UCSC:P04792 HSBP1
Reference Transcript
RefSeq:NM_001540.3 HSBP1
Other Identifiers
11756054_x_at
17047504
17125292
17125294
201841_3p_s_at
201841_PM_s_at
201841_s_at
3009401
3009402
3009403
3009404
3009405
3009406
3009407
3009408
3009409
3009410
3009411
3009412
3009413
3009414
3009415
3209482
3315
36785_at
4008010
63673_at
8133721
A_14_P101807
A_23_P257704
A_24_P86537
A_33_P3353242
GE79739
GO:0000502
GO:0001533
GO:0001932
GO:0003723
GO:0005080
GO:0005515
GO:0005615
GO:0005634
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006446
GO:0006457
GO:0006469
GO:0006886
GO:0006986
GO:0007018
GO:0007155
GO:0008426
GO:0009408
GO:0009615
GO:0010506
GO:0019901
GO:0030018
GO:0032731
GO:0032760
GO:0034620
GO:0035556
GO:0035924
GO:0042026
GO:0042802
GO:0042803
GO:0043066
GO:0043122
GO:0043130
GO:0043226
GO:0043292
GO:0043536
GO:0044183
GO:0045766
GO:0048010
GO:0051082
GO:0061077
GO:0061629
GO:0070062
GO:0070527
GO:0098772
GO:0099641
GO:1902176
GO:1904115
GO:2001028
GO:2001234
HMNXSV003032430
ILMN_1674236
PH_hs_0028972
TC07000485.hg
TC07000486.hg
TC07002418.hg
TC09002591.hg
Z23090_at
g4996892_3p_a_at
g4996892_3p_x_at
p26433
Participates
as an input of
p-S MAPKAPK5 phosphorylates HSPB1 (Homo sapiens)
AUF1 binds translation and heat shock proteins (Homo sapiens)
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Homo sapiens)
as a repeated unit of
HSBP1 oligomer [cytosol] (Homo sapiens)
Other forms of this molecule
p-S15,S78,S82-HSP27 [cytosol]
p-S78,S82 HSPB1 [cytosol]
Inferred To
hsp-12.3 [cytosol]
(Caenorhabditis elegans)
hsp-16.11 [cytosol]
(Caenorhabditis elegans)
HSPB1 [cytosol]
(Bos taurus)
HSPB1 [cytosol]
(Caenorhabditis elegans)
HSPB1 [cytosol]
(Gallus gallus)
HSPB1 [cytosol]
(Sus scrofa)
Dmel\CG7409 [cytosol]
(Drosophila melanogaster)
hspb1 [cytosol]
(Danio rerio)
hspb1 [cytosol]
(Xenopus tropicalis)
Hsp23 [cytosol]
(Drosophila melanogaster)
hsp-16.41 [cytosol]
(Caenorhabditis elegans)
Hsp27 [cytosol]
(Canis familiaris)
Hsp27 [cytosol]
(Drosophila melanogaster)
hsp-16.48 [cytosol]
(Caenorhabditis elegans)
hsp-17 [cytosol]
(Caenorhabditis elegans)
Dmel\CG13133 [cytosol]
(Drosophila melanogaster)
Hsp26 [cytosol]
(Drosophila melanogaster)
Hsp67Bc [cytosol]
(Drosophila melanogaster)
l(2)efl [cytosol]
(Drosophila melanogaster)
Hsp67Ba [cytosol]
(Drosophila melanogaster)
hsp-12.2 [cytosol]
(Caenorhabditis elegans)
hsp-16.2 [cytosol]
(Caenorhabditis elegans)
BEST:GH12586 [cytosol]
(Drosophila melanogaster)
Hsp22 [cytosol]
(Drosophila melanogaster)
sip-1 [cytosol]
(Caenorhabditis elegans)
Homologues of HSPB1 [cytosol]
(Caenorhabditis elegans)
Homologues of HSPB1 [cytosol]
(Drosophila melanogaster)
Hspb1 [cytosol]
(Mus musculus)
Hspb1 [cytosol]
(Rattus norvegicus)
hsp-43 [cytosol]
(Caenorhabditis elegans)
hsp-12.1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of HSPB1 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of HSPB1 [cytosol]
(Plasmodium falciparum)
hsp-12.6 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001531.1
OpenTargets
ENSG00000106211
ENSEMBL
ENSP00000248553
,
ENST00000248553
ZINC - Substances
HSPB1_HUMAN
ZINC target
P04792
PRO
P04792
GlyGen
P04792
PDB
6DV5
,
6GJH
,
2N3J
,
3Q9P
,
3Q9Q
,
4MJH
ZINC - Investigational
HSPB1_HUMAN
HPA
ENSG00000106211-HSPB1
Pharos - Targets
P04792
Orphanet
HSPB1
ZINC - Predictions - Purchasable
HSPB1_HUMAN
Interactors (237)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02511 CRYAB
1
CRYAB [nucleoplasm]
(R-HSA-6806336)
0.876
8
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.831
12
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.822
7
UniProt:P02489 CRYAA
0.815
7
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.706
21
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.678
4
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.666
4
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.666
4
UniProt:Q9BRX2 PELO
0.666
4
UniProt:P08865 RPSA
2
RPSA [cytosol]
(R-HSA-72389)
RPSA [nucleoplasm]
(R-HSA-6798722)
0.666
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.665
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.618
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.615
3
UniProt:Q9HBQ8 GGA2B
0.61
4
UniProt:P02602 MYL1
0.576
5
UniProt:P02562 MYSS
0.576
5
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.571
3
UniProt:Q16644 MAPKAPK3
4
MAPKAPK3 [nucleoplasm]
(R-HSA-450218)
p-S,2T-MAPKAPK3 [nucleoplasm]
(R-HSA-450359)
p-S,2T-MAPKAPK3 [cytosol]
(R-HSA-187723)
MAPKAPK3 [cytosol]
(R-HSA-187764)
0.571
3
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.564
2
UniProt:Q8IUI8 CRLF3
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:Q86V28 Q86V28
0.556
3
UniProt:Q96K21 ANCHR
0.556
3
UniProt:Q6PJW8-3 Q6PJW83
0.556
3
UniProt:Q9NSD5-3 Q9NSD53
0.556
3
UniProt:APLN D3DTF8
0.556
3
UniProt:Q9NTN9-3 SEMA4G
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q96D59 RN183
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:P11908 PRPS2
1
PRPS2 [cytosol]
(R-HSA-58224)
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:Q86TN1 Q86TN1
0.556
3
UniProt:Q9Y5P3 RAI2
0.556
3
UniProt:Q8N8A2-2 Q8N8A22
0.556
3
UniProt:Q99608 NDN
1
NDN [nucleoplasm]
(R-HSA-6789966)
0.556
3
IntAct:EBI-25859406 CCSB
0.556
3
UniProt:Q9H0W9-4 C11ORF54
0.556
3
UniProt:Q8N594 MPND
0.556
3
UniProt:P58304 VSX2
0.556
3
UniProt:Q14847-2 LASP1
0.556
3
UniProt:P08195-4 SLC3A2
0.556
3
UniProt:P0C870 JMJD7
1
JMJD7 [cytosol]
(R-HSA-9629577)
0.556
3
UniProt:Q49AJ0-4 Q49AJ04
0.556
3
UniProt:Q96LB9 PGLYRP3
1
PGLYRP3 [extracellular region]
(R-HSA-6799958)
0.556
3
UniProt:Q6P587-2 FAHD1
0.556
3
UniProt:Q96FW1 OTUB1
2
OTUB1 [nucleoplasm]
(R-HSA-6783242)
OTUB1 [cytosol]
(R-HSA-933411)
0.556
3
UniProt:Q8N6K7-2 SAMD3
0.556
3
UniProt:Q6UXG2-3 ELAPOR1
0.556
3
UniProt:P08758 ANXA5
2
ANXA5 [extracellular region]
(R-HSA-8862986)
ANXA5 [cytosol]
(R-HSA-8862945)
0.556
3
UniProt:P57682 KLF3
0.556
3
UniProt:Q7L8T7 Q7L8T7
0.556
3
UniProt:O00148 DDX39A
1
DDX39A [nucleoplasm]
(R-HSA-8852237)
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:Q9NSI6-4 BRWD1
0.556
3
UniProt:Q9NXC2 GFOD1
1
GFOD1 [plasma membrane]
(R-HSA-9714882)
0.556
3
IntAct:EBI-25840120 CCSB
0.556
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q92688 AN32B
0.556
3
UniProt:Q8NBM4-4 Q8NBM44
0.556
3
UniProt:P51608 MECP2
0.556
3
IntAct:EBI-25836220 CCSB
0.556
3
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.556
3
UniProt:A2RU56 A2RU56
0.556
3
UniProt:Q96N77-2 ZNF641
0.556
3
UniProt:Q5VWN6 TASO2
0.556
3
UniProt:A0A1B0GWI1 A0A1B0GWI1
0.556
3
UniProt:Q9BUF5 TUBB6
6
TUBB6 [cytosol]
(R-HSA-191698)
TUBB6 [axonemal microtubule]
(R-HSA-5610438)
Polyglutamyl-TUBB6 [cytosol]
(R-HSA-8867399)
Polyglycyl-TUBB6 [cytosol]
(R-HSA-8867396)
TUBB6 unfolded [cytosol]
(R-HSA-392780)
TUBB6 folding intermediate [cytosol]
(R-HSA-392787)
0.556
3
UniProt:Q969T4 UBE2E3
4
UBE2E3 [cytosol]
(R-HSA-947633)
UBE2E3 [nucleoplasm]
(R-HSA-8852108)
Ub-C145-UBE2E3 [nucleoplasm]
(R-HSA-8864208)
Ub-C145-UBE2E3 [cytosol]
(R-HSA-8864162)
0.556
3
UniProt:Q8NBJ7 SUMF2
1
SUMF2 [endoplasmic reticulum lumen]
(R-HSA-1614305)
0.556
3
UniProt:Q9UKP3-2 Q9UKP32
0.556
3
UniProt:Q8NBF2-2 NHLRC2
0.556
3
UniProt:Q06136 KDSR
1
KDSR [endoplasmic reticulum membrane]
(R-HSA-428134)
0.556
3
UniProt:Q9BS34 ZNF670
1
ZNF670 [nucleoplasm]
(R-HSA-2248887)
0.556
3
UniProt:Q96FT7-4 ASIC4
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:P62979 RPS27A
20
RPS27A(1-76) [endocytic vesicle membrane]
(R-HSA-939208)
RPS27A(77-156) [nucleoplasm]
(R-HSA-6798734)
Ub-33-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783024)
Ub-63-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783200)
Ub-6-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783040)
Ub-11-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783085)
Ub-48-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783075)
Ub-29-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783146)
Ub-63-RPS27A(1-76) [cytosol]
(R-HSA-939248)
RPS27A(1-76) [lysosomal lumen]
(R-HSA-9660001)
RPS27A(1-76) [cytosol]
(R-HSA-939205)
p-S65-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834951)
Ub-48-RPS27A(1-76) [cytosol]
(R-HSA-939202)
RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834993)
RPS27A(1-76) [late endosome lumen]
(R-HSA-9660022)
Ub-6-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782608)
Ub-63-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782503)
Ub-48-RPS27A(1-76) [nucleoplasm]
(R-HSA-5683037)
RPS27A(1-76) [nucleoplasm]
(R-HSA-939849)
Ub-11-RPS27A(1-76) [cytosol]
(R-HSA-3095933)
0.556
3
UniProt:Q96DZ5 CLIP3
1
CLIP3 [cytosol]
(R-HSA-5212669)
0.556
3
UniProt:Q96GL9 F163A
0.556
3
UniProt:Q99614 TTC1
0.556
3
UniProt:Q5TAQ9-2 Q5TAQ92
0.556
3
UniProt:O00757 FBP2
1
FBP2 [cytosol]
(R-HSA-71500)
0.556
3
IntAct:EBI-25835277 CCSB
0.556
3
UniProt:Q9NP61 ARFGAP3
1
ARFGAP3 [cytosol]
(R-HSA-6807740)
0.556
3
UniProt:Q53NU3 Q53NU3
0.556
3
UniProt:Q96A09 TET5B
0.556
3
UniProt:Q8NA54 IQUB
0.556
3
UniProt:Q96SI1-2 KCTD15
0.556
3
UniProt:Q9NZJ9 NUDT4
1
NUDT4 [cytosol]
(R-HSA-1604676)
0.556
3
UniProt:Q96JB6 LOXL4
3
LOXL4(25-?) [extracellular region]
(R-HSA-2022087)
LOXL4 [extracellular region]
(R-HSA-2022127)
LOXL4(?-756) [extracellular region]
(R-HSA-2022098)
0.556
3
UniProt:A0A0A0MR05 A0A0A0MR05
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
IntAct:EBI-25831465 CCSB
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
3
UniProt:O95872 GPAN1
0.556
3
UniProt:Q7L591-3 DOK3
0.556
3
UniProt:Q8TBF4 ZCRB1
2
ZCRB1 [cytosol]
(R-HSA-9682010)
ZCRB1 [nucleoplasm]
(R-HSA-6787853)
0.556
3
IntAct:EBI-25857950 CCSB
0.556
3
UniProt:Q17RD7-3 Q17RD73
0.556
3
UniProt:Q13569 TDG
3
TDG [nucleoplasm]
(R-HSA-65812)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
0.556
3
UniProt:Q9NXX0 Q9NXX0
0.556
3
UniProt:Q8TC84 FANK1
0.556
3
UniProt:Q8IXS7 Q8IXS7
0.556
3
UniProt:A0AVI4-2 A0AVI42
0.556
3
UniProt:Q2QGD7 ZXDC
0.556
3
UniProt:P15313 ATP6V1B1
1
ATP6V1B1 [cytosol]
(R-HSA-912604)
0.556
3
UniProt:Q58EX7-2 Q58EX72
0.556
3
UniProt:Q96LL4 CH048
0.556
3
UniProt:Q8IYI0 SHLD1
0.556
3
UniProt:B7Z3E8 B7Z3E8
0.556
3
UniProt:Q5BJF6-2 ODF2
0.556
3
UniProt:O94778 AQP8
2
AQP8 [plasma membrane]
(R-HSA-431756)
AQP8 [mitochondrial inner membrane]
(R-HSA-3779402)
0.556
3
UniProt:P45880 VDAC2
6
p-S65-Ub:VDAC2 [mitochondrial outer membrane]
(R-HSA-9834982)
K63polyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-9843314)
K48polyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-9843321)
Ub-VDAC2 [mitochondrial outer membrane]
(R-HSA-9835025)
VDAC2 [mitochondrial outer membrane]
(R-HSA-5696880)
PolyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-6783185)
0.556
3
UniProt:Q6ZU52 K0408
0.556
3
IntAct:EBI-25870739 RZPDO834G0119D
0.556
3
UniProt:Q8TDP1 RNH2C
0.556
3
UniProt:Q3SYF9 KRTAP19-7
1
KRTAP19-7 [cytosol]
(R-HSA-6810305)
0.556
3
UniProt:Q8WZ19 KCTD13
1
KCTD13 [cytosol]
(R-HSA-9696533)
0.556
3
UniProt:P01040 CSTA
2
CSTA [cornified envelope]
(R-HSA-8934840)
CSTA [cytosol]
(R-HSA-6814194)
0.556
3
UniProt:Q8WUY3 PRUN2
0.556
3
UniProt:Q8N6F8 MET27
0.556
3
UniProt:Q9Y3D0 CIAO2B
1
FAM96B [cytosol]
(R-HSA-2161124)
0.556
3
UniProt:P28062-2 PSMB8
0.556
3
UniProt:O43741 PRKAB2
2
PRKAB2 [cytosol]
(R-HSA-200413)
PRKAB2 [nucleoplasm]
(R-HSA-164096)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:P21980-2 P219802
0.556
3
UniProt:P13928 ANXA8
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:Q15049 MLC1
0.556
3
UniProt:Q8N5U6 RNF10
0.556
3
UniProt:Q6P1L5 F117B
0.556
3
UniProt:Q14995 NR1D2
1
NR1D2 [nucleoplasm]
(R-HSA-375501)
0.556
3
IntAct:EBI-25839678 CCSB
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q9Y3Q8 T22D4
0.556
3
UniProt:Q6ZTN6-2 ANKRD13D
0.556
3
IntAct:EBI-25849442 CCSB
0.556
3
UniProt:Q8NDP9 Q8NDP9
0.556
3
IntAct:EBI-25835866 CCSB
0.556
3
UniProt:Q9H9Q2 COPS7B
2
COPS7B [nucleoplasm]
(R-HSA-5697023)
COPS7B [cytosol]
(R-HSA-416966)
0.556
3
UniProt:Q8N5S9-2 Q8N5S92
0.556
3
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.556
3
UniProt:Q8IUR5-4 TMTC1
0.556
3
UniProt:Q8NA72-3 POC5
0.556
3
IntAct:EBI-25836274 CCSB
0.556
3
UniProt:O75604-3 USP2
0.556
3
UniProt:Q9UNS2 COPS3
2
COPS3 [nucleoplasm]
(R-HSA-5697017)
COPS3 [cytosol]
(R-HSA-416973)
0.556
3
UniProt:Q9NVX7-2 Q9NVX72
0.556
3
UniProt:Q03112-9 Q031129
0.556
3
UniProt:P15976-2 GATA1
0.556
3
UniProt:Q9BPU6 DPYSL5
3
p-S534-DPYSL5 [cytosol]
(R-HSA-399793)
p-Y-DPYSL5 [cytosol]
(R-HSA-399786)
DPYSL5 [cytosol]
(R-HSA-398138)
0.556
3
UniProt:Q9UF11-2 PLEKHB1
0.556
3
IntAct:EBI-25835770 CCSB
0.556
3
UniProt:O15381-5 O153815
0.556
3
UniProt:Q6RVD6 SPAT8
0.556
3
UniProt:P36639-4 NUDT1
1
NUDT1-4 [cytosol]
(R-HSA-2395813)
0.556
3
UniProt:Q6ZR37 PKHG7
0.556
3
UniProt:Q92966 SNAPC3
1
SNAPC3 [nucleoplasm]
(R-HSA-83727)
0.556
3
UniProt:O60830 TIMM17B
2
TIMM17B [mitochondrial intermembrane space]
(R-HSA-1955371)
TIMM17B [mitochondrial inner membrane]
(R-HSA-1252138)
0.556
3
UniProt:Q8IYN2 TCAL8
0.556
3
UniProt:Q71RG4-4 Q71RG44
0.556
3
UniProt:Q9UDY8-2 MALT1
0.556
3
UniProt:Q04323-2 UBXN1
0.556
3
UniProt:Q8WVN8 UBE2Q2
2
Ub-C304-UBE2Q2 [cytosol]
(R-HSA-8864218)
UBE2Q2 [cytosol]
(R-HSA-947618)
0.556
3
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.556
3
UniProt:A0A384ME25 A0A384ME25
0.556
3
IntAct:EBI-25861384 CCSB
0.556
3
UniProt:Q9UPM6 LHX6
0.556
3
UniProt:Q8N1A0 KT222
0.556
3
UniProt:Q9HC96 CAPN10
1
CAPN10 [cytosol]
(R-HSA-8848640)
0.556
3
UniProt:Q8TCT7-2 SPPL2B
0.556
3
UniProt:Q17RN3 FA98C
0.556
3
UniProt:Q16670 ZSC26
0.556
3
UniProt:Q8IUC2 KRTAP8-1
1
KRTAP8-1 [cytosol]
(R-HSA-6810288)
0.556
3
IntAct:EBI-25831516 CCSB
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
IntAct:EBI-25835796 CCSB
0.556
3
UniProt:O77932 DXO
0.556
3
UniProt:Q9NZC7-5 WWOX
0.556
3
UniProt:Q9C004 SPY4
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:Q5VYS8-5 TUT7
0.556
3
UniProt:Q9Y575-3 ASB3
0.556
3
IntAct:EBI-25848398 CCSB
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
IntAct:EBI-25843264 CCSB
0.556
3
UniProt:Q6GQQ9-2 Q6GQQ92
0.556
3
UniProt:P61244-4 MAX
0.556
3
UniProt:Q7Z602 GP141
0.556
3
UniProt:hCG_41307 A0A024R1L7
0.556
3
IntAct:EBI-25851697 CCSB
0.556
3
UniProt:Q9Y4H4 GPSM3
1
GPSM3 [cytosol]
(R-HSA-8949486)
0.556
3
UniProt:Q96EW2-2 Q96EW22
0.556
3
UniProt:Q14457 BECN1
4
BECN1 [cytosol]
(R-HSA-1632841)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:P62244 RPS15A
2
RPS15A [cytosol]
(R-HSA-72345)
RPS15A [nucleoplasm]
(R-HSA-6791191)
0.556
3
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.556
3
UniProt:Q86WV5 TEN1
1
TEN1 [nucleoplasm]
(R-HSA-9668823)
0.556
3
UniProt:Q96FX8 PERP
1
PERP [plasma membrane]
(R-HSA-6800837)
0.556
3
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:Q14693 LPIN1
3
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:Q8N5V2 NGEF
2
NGEF [cytosol]
(R-HSA-3006800)
p-Y179-NGEF [cytosol]
(R-HSA-3928441)
0.556
3
UniProt:Q9BQA1 WDR77
3
WDR77 [cytosol]
(R-HSA-191823)
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [nucleoplasm]
(R-HSA-5205610)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:Q8N448 LNX2
0.556
3
UniProt:Q9H1D9 POLR3F
2
POLR3F [cytosol]
(R-HSA-1964434)
POLR3F [nucleoplasm]
(R-HSA-83708)
0.556
3
UniProt:Q9NUL5-3 SHFL
0.556
3
UniProt:P51114 FXR1
2
FXR1(2-784)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802326)
FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802530)
0.553
2
UniProt:P35813 PPM1A
2
PPM1A [nucleoplasm]
(R-HSA-205813)
PPM1A [cytosol]
(R-HSA-380928)
0.553
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.547
3
UniProt:P08473 MME
2
MME [secretory granule membrane]
(R-HSA-6806156)
MME [plasma membrane]
(R-HSA-2022342)
0.537
4
UniProt:O14558 HSPB6
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.527
3
UniProt:Q14240 EIF4A2
1
EIF4A2 [cytosol]
(R-HSA-72575)
0.508
2
UniProt:Q7Z6Z7 HUWE1
4
HUWE1 [ficolin-1-rich granule lumen]
(R-HSA-6801467)
HUWE1 [extracellular region]
(R-HSA-6806466)
HUWE1 [secretory granule lumen]
(R-HSA-6801481)
HUWE1 [cytosol]
(R-HSA-975983)
0.508
3
UniProt:P13693 TCTP
0.508
2
UniProt:P02794 FTH1
5
FTH1 [cytosol]
(R-HSA-434212)
FTH1 [tertiary granule lumen]
(R-HSA-6801508)
FTH1 [extracellular region]
(R-HSA-2187212)
FTH1 [ficolin-1-rich granule lumen]
(R-HSA-6801531)
FTH1 [endocytic vesicle lumen]
(R-HSA-2299670)
0.508
2
UniProt:Q9Y657 SPIN1
0.508
2
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.508
2
UniProt:P13010 XRCC5
4
XRCC5 [nucleoplasm]
(R-HSA-58274)
XRCC5 [cytosol]
(R-HSA-3134849)
XRCC5 [secretory granule lumen]
(R-HSA-6801297)
XRCC5 [extracellular region]
(R-HSA-6806530)
0.508
2
UniProt:Q8N7H5 PAF1
1
PAF1 [nucleoplasm]
(R-HSA-8866689)
0.508
2
UniProt:P78318 IGBP1
0.508
3
UniProt:Q86YS6 RAB43
3
RAB43 [trans-Golgi network membrane]
(R-HSA-6814810)
GGC-RAB43 [cytosol]
(R-HSA-8874038)
RAB43 [cytosol]
(R-HSA-6813902)
0.508
2
UniProt:Q96G03 PGM2
4
PGM2 [cytosol]
(R-HSA-453136)
PGM2 [ficolin-1-rich granule lumen]
(R-HSA-6801476)
PGM2 [extracellular region]
(R-HSA-6806446)
PGM2 [secretory granule lumen]
(R-HSA-6801502)
0.508
2
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.508
2
UniProt:P78417 GSTO1
1
GSTO1 [cytosol]
(R-HSA-176043)
0.508
2
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.508
2
UniProt:P78344 EIF4G2
1
EIF4G2 [cytosol]
(R-HSA-1678826)
0.508
3
UniProt:Q12874 SF3A3
1
SF3A3 [nucleoplasm]
(R-HSA-71966)
0.508
2
UniProt:O00273 DFFA
6
DFFA [cytosol]
(R-HSA-211221)
DFFA(1-?) [nucleoplasm]
(R-HSA-211228)
DFFA(225-331) [nucleoplasm]
(R-HSA-211188)
DFFA(118-224) [nucleoplasm]
(R-HSA-211205)
DFFA(118-331) [nucleoplasm]
(R-HSA-211199)
DFFA(1-117) [nucleoplasm]
(R-HSA-211185)
0.508
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.483
3
UniProt:Q9UJY1 HSPB8
1
HSPB8 [nucleoplasm]
(R-HSA-6806337)
0.454
3
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