Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Stable Identifier
Homo sapiens
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Tristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the decapping enzymes DCP1 and DCP2a.
The activity of TTP is regulated by phosphorylation. MK2 phosphorylates TTP, which then binds 14-3-3.The interaction with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound by phosphorylated TTP. Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos). Mice deficient in TTP exhibit arthritis, weight loss, skin lesions, autoimmunity, and myeloid hyperplasia.

Literature References
PubMed ID Title Journal Year
18481987 Control of mRNA decay by phosphorylation of tristetraprolin

Stoecklin, G, Sandler, H

Biochem Soc Trans 2008
16391004 AU-rich elements and associated factors: are there unifying principles?

Barreau, C, Paillard, L, Osborne, HB

Nucleic Acids Res 2005
12704645 Post-transcriptional regulation of gene expression by degradation of messenger RNAs

Ceriani, MC, Bevilacqua, A, Capaccioli, S, Nicolin, A

J Cell Physiol 2003
12440953 AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors

Kruys, V, Zhang, T, Huez, G, Gueydan, C

Biochem Soc Trans 2002
Event Information
Orthologous Events
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