Protein Kinase B (AKT) phosphorylates KSRP

Stable Identifier
R-HSA-450499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Protein Kinase B (AKT) phosphorylates KSRP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
KSRP is phosphorylated by activated protein kinase B/AKT at serine 193 (Diaz-Moreno et al. 2009). Phosphorylation does not prevent KSRP from binding RNA.
Literature References
PubMed ID Title Journal Year
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Diaz-Moreno, I, Hollingworth, D, Frenkiel, TA, Kelly, G, Martin, S, Howell, S, Garcia-Mayoral, M, Gherzi, R, Briata, P, Ramos, A

Nat Struct Mol Biol 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Physical Entity
p-T308,S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)
Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)
Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)
Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)
Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
Cite Us!