Protein Kinase B (AKT) phosphorylates KSRP

Stable Identifier
R-HSA-450499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Protein Kinase B (AKT) phosphorylates KSRP
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KSRP is phosphorylated by activated protein kinase B/AKT at serine 193. Phosphorylation does not prevent KSRP from binding RNA.

Literature References
PubMed ID Title Journal Year
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Briata, P, Martin, S, Ramos, A, Frenkiel, TA, Garcia-Mayoral, M, Diaz-Moreno, I, Gherzi, R, Hollingworth, D, Kelly, G, Howell, S

Nat Struct Mol Biol 2009
17177604 The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

Briata, P, Khabar, KS, Andersen, JS, Ruggiero, T, Trabucchi, M, Ponassi, M, Gherzi, R, Chen, CY, Moroni, C, Corte, G

PLoS Biol 2006
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

Physical Entity
p-T308,S473-AKT1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)
Protein Kinase B (AKT) phosphorylates KSRP (Canis familiaris)
Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)
Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)
Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)
Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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