Protein Kinase B (AKT) phosphorylates KSRP

Stable Identifier
R-HSA-450499
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

KSRP is phosphorylated by activated protein kinase B/AKT at serine 193. Phosphorylation does not prevent KSRP from binding RNA.

Literature References
PubMed ID Title Journal Year
17177604 The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

Gherzi, R, Trabucchi, M, Ponassi, M, Ruggiero, T, Corte, G, Moroni, C, Chen, CY, Khabar, KS, Andersen, JS, Briata, P

PLoS Biol 2006
19198587 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

Diaz-Moreno, I, Hollingworth, D, Frenkiel, TA, Kelly, G, Martin, S, Howell, S, Garcia-Mayoral, M, Gherzi, R, Briata, P, Ramos, A

Nat Struct Mol Biol 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created