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p-S60,S186-ZFP36 [cytosol]
Stable Identifier
R-HSA-450496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S186,S60-ZFP36, Tristetraproline with phosphoserine60 and phosphoserine186, ZFP36, TTP_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA (Homo sapiens)
MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)
Phosphorylated TTP:mRNA Complex [cytosol] (Homo sapiens)
p-S60,S186-ZFP36 [cytosol] (Homo sapiens)
p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)
Phosphorylated TTP:mRNA Complex [cytosol] (Homo sapiens)
p-S60,S186-ZFP36 [cytosol] (Homo sapiens)
Phosphorylated TTP:mRNA:14-3-3 Complex [cytosol] (Homo sapiens)
Phosphorylated TTP:mRNA Complex [cytosol] (Homo sapiens)
p-S60,S186-ZFP36 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26651 ZFP36
Gene Names
ZFP36, G0S24, NUP475, RNF162A, TIS11A, TTP
Chain
chain:1-326
Reference Genes
BioGPS Gene:7538 ZFP36
COSMIC (genes):ZFP36 ZFP36
CTD Gene:7538 ZFP36
dbSNP Gene:7538 ZFP36
ENSEMBL:ENSG00000128016 ZFP36
ENSEMBL_homo_sapiens_GENE:ENSG00000128016.7 ZFP36
HGNC:12862 ZFP36
KEGG Gene (Homo sapiens):7538 ZFP36
Monarch:7538 ZFP36
NCBI Gene:7538 ZFP36
OMIM:190700 ZFP36
Reference Transcript
RefSeq:NM_003407.3 ZFP36
Other Identifiers
11715691_s_at
16861997
201531_PM_at
201531_at
3832979
3832986
3832987
3832988
3832989
40448_at
7538
8028652
A_14_P113816
A_23_P39237
GE58147
GO:0000122
GO:0000165
GO:0000288
GO:0000289
GO:0000932
GO:0002376
GO:0003677
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006402
GO:0006954
GO:0009611
GO:0010494
GO:0010837
GO:0012501
GO:0016071
GO:0019899
GO:0019901
GO:0019957
GO:0023052
GO:0030014
GO:0030099
GO:0030154
GO:0031047
GO:0031072
GO:0031086
GO:0032680
GO:0032703
GO:0032897
GO:0035278
GO:0035556
GO:0035925
GO:0038066
GO:0042594
GO:0043226
GO:0043488
GO:0044344
GO:0044877
GO:0045600
GO:0045616
GO:0045638
GO:0045647
GO:0046872
GO:0048856
GO:0050728
GO:0050779
GO:0051028
GO:0060213
GO:0060218
GO:0061014
GO:0061158
GO:0070063
GO:0070935
GO:0071222
GO:0071356
GO:0071364
GO:0071385
GO:0071889
GO:0097011
GO:1900153
GO:1901835
GO:1902037
GO:1902172
GO:1904246
GO:1904582
GO:1990904
GO:2000637
HMNXSV003028810
ILMN_1720829
M92843_s_at
PH_hs_0016638
TC19000544.hg
g4507960_3p_at
Participates
as a component of
Phosphorylated TTP:mRNA Complex [cytosol] (Homo sapiens)
Other forms of this molecule
ZFP36 [cytosol]
Inferred To
phospho-ZFP36 [cytosol]
(Bos taurus)
phospho-ZFP36 [cytosol]
(Canis familiaris)
phospho-ZFP36 [cytosol]
(Sus scrofa)
phospho-oma-2 [cytosol]
(Caenorhabditis elegans)
phospho-mex-1 [cytosol]
(Caenorhabditis elegans)
phospho-oma-1 [cytosol]
(Caenorhabditis elegans)
phospho-Zfp36 [cytosol]
(Mus musculus)
phospho-Zfp36 [cytosol]
(Rattus norvegicus)
phospho-dct-13 [cytosol]
(Caenorhabditis elegans)
phospho-ccch-2 [cytosol]
(Caenorhabditis elegans)
phospho-Tis11 [cytosol]
(Drosophila melanogaster)
Homologues of p-S60,S186-ZFP36 [cytosol]
(Caenorhabditis elegans)
Homologues of p-S60,S186-ZFP36 [cytosol]
(Saccharomyces cerevisiae)
phospho-ccch-1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S60,S186-ZFP36 [cytosol]
(Caenorhabditis elegans)
phospho-p-S60,S186-ZFP36 [cytosol]
(Dictyostelium discoideum)
phospho-pie-1 [cytosol]
(Caenorhabditis elegans)
phospho-CTH1 [cytosol]
(Saccharomyces cerevisiae)
phospho-mex-5 [cytosol]
(Caenorhabditis elegans)
phospho-mex-6 [cytosol]
(Caenorhabditis elegans)
phospho-zfs1 [cytosol]
(Schizosaccharomyces pombe)
phospho-ccch-5 [cytosol]
(Caenorhabditis elegans)
phospho-moe-3 [cytosol]
(Caenorhabditis elegans)
phospho-TIS11 [cytosol]
(Saccharomyces cerevisiae)
phospho-zfp36 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 60
Coordinate
60
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 186
Coordinate
186
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_003398.2
OpenTargets
ENSG00000128016
HPA
ENSG00000128016-ZFP36
GeneCards
P26651
Ensembl
ENST00000597629
,
ENSP00000469647
,
ENSG00000128016
PRO
P26651
Pharos - Targets
P26651
HMDB Protein
HMDBP13857
PDB
4J8S
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A5YKK6-2 CNOT1
0.618
4
UniProt:Q06455-2 RUNX1T1
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:Q96F86 EDC3
1
EDC3 [cytosol]
(R-HSA-429997)
0.499
2
UniProt:Q9NPI6 DCP1A
1
DCP1A [cytosol]
(R-HSA-430043)
0.499
2
UniProt:Q13643 FHL3
0.488
4
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