HuR binds mRNAs in the nucleus

Stable Identifier
Reaction [binding]
Homo sapiens
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HuR binds AU-rich elements of mRNAs. Bound HuR can form oligomers on longer AU-rich elements. Phosphorylated HuR binds mRNA more tightly than unphosphorylated HuR does.

Literature References
PubMed ID Title Journal Year
16484227 Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element

Schirmer, S, Stülke, J, Hauber, J, Langbein-Detsch, I, Kehlenbach, RH, Ehlers, C, Chemnitz, J, Dabauvalle, MC, Prechtel, AT

J Biol Chem 2006
17517897 Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences

Willis, CD, Toth, EA, Ballin, JD, Wilson, GM, Brewer, BY, Fialcowitz-White, EJ

J Biol Chem 2007
14981256 Identification of a target RNA motif for RNA-binding protein HuR

Gorospe, M, Yang, X, López de Silanes, I, Lal, A, Zhan, M

Proc Natl Acad Sci U S A 2004
11834731 A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR

Furneauxb, H, Goldberg-Cohen, I, Levy, AP

J Biol Chem 2002
11018049 Protein ligands to HuR modulate its interaction with target mRNAs in vivo

Gallouzi, IE, Steitz, JA, Brennan, CM

J Cell Biol 2000
Orthologous Events
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