Reactome | HuR binds mRNAs in the nucleus

HuR binds mRNAs in the nucleus

Stable Identifier

R-HSA-450494

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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HuR binds AU-rich elements of mRNAs. Bound HuR can form oligomers on longer AU-rich elements. Phosphorylated HuR binds mRNA more tightly than unphosphorylated HuR does.

Literature References

PubMed ID	Title	Journal	Year
16484227	Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element Schirmer, S, Stülke, J, Hauber, J, Langbein-Detsch, I, Kehlenbach, RH, Ehlers, C, Chemnitz, J, Dabauvalle, MC, Prechtel, AT	J Biol Chem	2006
17517897	Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences Willis, CD, Toth, EA, Ballin, JD, Wilson, GM, Brewer, BY, Fialcowitz-White, EJ	J Biol Chem	2007
14981256	Identification of a target RNA motif for RNA-binding protein HuR Gorospe, M, Yang, X, López de Silanes, I, Lal, A, Zhan, M	Proc Natl Acad Sci U S A	2004
11834731	A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR Furneauxb, H, Goldberg-Cohen, I, Levy, AP	J Biol Chem	2002
11018049	Protein ligands to HuR modulate its interaction with target mRNAs in vivo Gallouzi, IE, Steitz, JA, Brennan, CM	J Cell Biol	2000