p-S92,203-BRF1 binds 14-3-3

Stable Identifier
R-HSA-450406
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Phosphorylated BRF1 interacts with 14-3-3, becomes localized to the cytoskeleton, and no longer promotes RNA degradation. Phosphorylated BRF1 is, however, still able to bind RNA.

Literature References
PubMed ID Title Journal Year
15538381 The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

Schmidlin, M, Lu, M, Leuenberger, SA, Stoecklin, G, Mallaun, M, Gross, B, Gherzi, R, Hess, D, Hemmings, BA, Moroni, C

EMBO J 2004
17030608 BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites

Benjamin, D, Schmidlin, M, Min, L, Gross, B, Moroni, C

Mol Cell Biol 2006
Participants
Participant Of
Orthologous Events
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