p-S92,203-BRF1 binds 14-3-3

Stable Identifier
R-HSA-450406
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-S92,203-BRF1 binds 14-3-3
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Phosphorylated BRF1 interacts with 14-3-3, becomes localized to the cytoskeleton, and no longer promotes RNA degradation. Phosphorylated BRF1 is, however, still able to bind RNA.
Literature References
PubMed ID Title Journal Year
17030608 BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites

Gross, B, Benjamin, D, Min, L, Moroni, C, Schmidlin, M

Mol Cell Biol 2006
15538381 The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

Stoecklin, G, Lu, M, Hess, D, Gross, B, Mallaun, M, Leuenberger, SA, Gherzi, R, Moroni, C, Hemmings, BA, Schmidlin, M

EMBO J 2004
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Orthologous Events
p-S92,203-BRF1 binds 14-3-3 (Bos taurus)
p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)
p-S92,203-BRF1 binds 14-3-3 (Danio rerio)
p-S92,203-BRF1 binds 14-3-3 (Drosophila melanogaster)
p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)
p-S92,203-BRF1 binds 14-3-3 (Mus musculus)
p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)
p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)
p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-17)
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