p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated tristetraproline (TTP) binds 14-3-3, which inhibits the ability of TTP to destabilize RNA. Thus RNAs bound by TTP become stabilized. The binding of 14-3-3 causes TTP to be excluded from stress granules.

Literature References
PubMed ID Title Journal Year
18481987 Control of mRNA decay by phosphorylation of tristetraprolin

Stoecklin, G, Sandler, H

Biochem Soc Trans 2008
15014438 MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

Stubbs, T, Stoecklin, G, Blackwell, TK, Kedersha, N, Rigby, WF, Anderson, P, Wax, S

EMBO J 2004
14688255 MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

Shabanowitz, J, Sturgill, TW, Hunt, DF, Schroeder, MJ, Chrestensen, CA, Pelo, JW, Worthington, MT

J Biol Chem 2004
15944294 Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function

Bloch, DB, Collins, J, Roy, K, Brooks, SA, Rigby, S, Rigby, WF, Connolly, JE

J Immunol 2005
Orthologous Events
Cite Us!