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ATF2 [nucleoplasm]
Stable Identifier
R-HSA-450336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ATF-2, Cyclic AMP-dependent transcription factor ATF-2
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8IUH5 ZDH17
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
ATF2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15336 ATF2
Gene Names
ATF2, CREB2, CREBP1
Chain
chain:1-505
Reference Genes
BioGPS Gene:1386 ATF2
COSMIC (genes):ATF2 ATF2
CTD Gene:1386 ATF2
dbSNP Gene:1386 ATF2
ENSEMBL:ENSG00000115966 ATF2
ENSEMBL_homo_sapiens_GENE:ENSG00000115966.18 ATF2
HGNC:784 ATF2
KEGG Gene (Homo sapiens):1386 ATF2
Monarch:1386 ATF2
NCBI Gene:1386 ATF2
OMIM:123811 ATF2
UCSC:P15336 ATF2
Reference Transcript
RefSeq:NM_001256090.1 ATF2
RefSeq:NM_001880.3 ATF2
RefSeq:NM_001256092.1 ATF2
RefSeq:NM_001256094.1 ATF2
RefSeq:NM_001256091.1 ATF2
RefSeq:NM_001256093.1 ATF2
Other Identifiers
11739868_a_at
11750233_a_at
11750480_a_at
11761942_at
11763586_s_at
1386
1555146_PM_at
1555146_at
16905322
1994_at
205446_PM_s_at
205446_s_at
212984_PM_at
212984_at
2588067
2588068
2588069
2588070
2588071
2588072
2588073
2588075
2588080
2588081
2588082
2588086
2588091
2588092
2588093
2588094
2588095
2588096
2588098
2588099
2588103
2588104
2588106
2588107
2588112
2588113
2588114
2588115
2588116
37575_at
38902_r_at
8056909
A_23_P209879
A_24_P128145
A_24_P246467
GE56268
GE81083
GO:0000122
GO:0000165
GO:0000278
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001701
GO:0001865
GO:0001889
GO:0001934
GO:0002244
GO:0002376
GO:0003151
GO:0003360
GO:0003418
GO:0003419
GO:0003677
GO:0003682
GO:0003700
GO:0003824
GO:0004402
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0006915
GO:0006970
GO:0006974
GO:0007005
GO:0007010
GO:0007033
GO:0007254
GO:0007507
GO:0008140
GO:0010467
GO:0010485
GO:0010628
GO:0012501
GO:0014070
GO:0016020
GO:0016071
GO:0016525
GO:0016740
GO:0018107
GO:0019901
GO:0021742
GO:0021743
GO:0021754
GO:0023052
GO:0030154
GO:0030509
GO:0031573
GO:0032915
GO:0034599
GO:0035497
GO:0035861
GO:0036211
GO:0038066
GO:0042789
GO:0042802
GO:0042803
GO:0043226
GO:0043522
GO:0043565
GO:0044013
GO:0044255
GO:0045815
GO:0045944
GO:0046872
GO:0046982
GO:0048856
GO:0050872
GO:0051091
GO:0060052
GO:0060245
GO:0060612
GO:0061024
GO:0061629
GO:0072740
GO:0090575
GO:0097049
GO:0097284
GO:0098586
GO:0110024
GO:0140096
GO:0140110
GO:1902110
GO:1902562
GO:1902742
GO:1990144
GO:1990253
GO:1990837
GO:1990841
HMNXSV003049237
HMNXSV003055076
Hs.80285.0.S1_3p_at
Hs2.198166.2.S1_3p_at
Hs2.198166.2.S1_3p_x_at
ILMN_1748271
PH_hs_0022193
TC02002545.hg
TC02004705.hg
X15875_at
g4503032_3p_a_at
Participates
as an input of
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Other forms of this molecule
p-T69,T71-ATF2 [nucleoplasm]
Inferred To
Atf2 [nucleoplasm]
(Mus musculus)
Atf2 [nucleoplasm]
(Rattus norvegicus)
atf1 [nucleoplasm]
(Schizosaccharomyces pombe)
SKO1 [nucleoplasm]
(Saccharomyces cerevisiae)
atf-7 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of ATF2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of ATF2 [nucleoplasm]
(Schizosaccharomyces pombe)
ACA1 [nucleoplasm]
(Saccharomyces cerevisiae)
ATF2 [nucleoplasm]
(Canis familiaris)
ATF2 [nucleoplasm]
(Gallus gallus)
ATF2 [nucleoplasm]
(Sus scrofa)
CST6 [nucleoplasm]
(Saccharomyces cerevisiae)
Atf-2 [nucleoplasm]
(Drosophila melanogaster)
atf2 [nucleoplasm]
(Xenopus tropicalis)
atf21 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001243019.1
,
NP_001243023.1
,
NP_001243020.1
,
NP_001871.2
,
NP_001243022.1
,
NP_001243021.1
OpenTargets
ENSG00000115966
HPA
ENSG00000115966-ATF2
GeneCards
P15336
Ensembl
ENST00000409499
,
ENSP00000340576
,
ENST00000409635
,
ENST00000426833
,
ENST00000392544
,
ENST00000264110
,
ENST00000409833
,
ENSP00000264110
,
ENSP00000386526
,
ENSP00000407911
,
ENSG00000115966
,
ENSP00000386282
,
ENST00000345739
,
ENSP00000376327
,
ENSP00000387093
PRO
P15336
Pharos - Targets
P15336
HMDB Protein
HMDBP08112
PDB
6ZQS
,
4H36
,
1T2K
,
6ZR5
,
1BHI
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.95
22
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.937
15
UniProt:P15408 FOSL2
0.811
8
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.781
9
UniProt:Q9NR55 BATF3
0.779
5
UniProt:P17275 JUNB
1
JUNB [nucleoplasm]
(R-HSA-2186795)
0.764
6
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.718
6
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.713
3
UniProt:O14867 BACH1
5
BACH1 [nucleoplasm]
(R-HSA-9707688)
BACH1 [cytosol]
(R-HSA-9708429)
PolyUb-BACH1 [nucleoplasm]
(R-HSA-9708486)
p-Y483 BACH1 [nucleoplasm]
(R-HSA-9762202)
p-Y483 BACH1 [cytosol]
(R-HSA-9762206)
0.713
3
UniProt:P18847 ATF3
1
ATF3 [nucleoplasm]
(R-HSA-535543)
0.713
5
UniProt:P17535 JUND
1
JUND [nucleoplasm]
(R-HSA-9009924)
0.688
6
UniProt:P53539 FOSB
1
FOSB [nucleoplasm]
(R-HSA-9009922)
0.666
5
UniProt:Q7L2Z9 CENPQ
2
CENPQ [nucleoplasm]
(R-HSA-606327)
CENPQ [cytosol]
(R-HSA-375298)
0.666
5
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.623
2
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.592
2
UniProt:P17544 ATF7
0.59
4
UniProt:P15407 FOSL1
1
FOSL1 [nucleoplasm]
(R-HSA-9620405)
0.59
3
UniProt:P19367 HK1
4
HK1 T680S [cytosol]
(R-HSA-5621880)
HK1 H577_C672del [cytosol]
(R-HSA-5621873)
HK1 L529S [cytosol]
(R-HSA-5621861)
HK1 [cytosol]
(R-HSA-70395)
0.576
4
UniProt:P21796 VDAC1
7
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
0.576
3
UniProt:Q99986 VRK1
2
VRK1 [nucleoplasm]
(R-HSA-2528998)
VRK1 [cytosol]
(R-HSA-2995381)
0.571
5
UniProt:P0C746 HBZ
0.558
3
UniProt:O75928-2 PIAS2
1
PIAS2-2 [nucleoplasm]
(R-HSA-2993779)
0.556
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.556
3
UniProt:Q68G74 LHX8
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q6FG41 Q6FG41
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q6IQ16 SPOPL
1
SPOPL [nucleoplasm]
(R-HSA-5635036)
0.556
3
UniProt:Q8WYK2 JDP2
0.547
2
UniProt:A4PIW0 A4PIW0
0.532
11
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
2
UniProt:O76038 SEGN
0.527
3
UniProt:Q9NS91 RAD18
1
RAD18 [nucleoplasm]
(R-HSA-5643731)
0.527
2
UniProt:P55198 AF17
0.527
2
UniProt:Q9Y4X5 ARIH1
1
ARIH1 [cytosol]
(R-HSA-1678825)
0.527
2
UniProt:Q8IUH5 ZDH17
0.508
3
UniProt:O95644 NFATC1
3
p-S257-NFATC1 [nucleoplasm]
(R-HSA-2025935)
p-S257-NFATC1 [cytosol]
(R-HSA-2685618)
p-12S-NFATC1 [cytosol]
(R-HSA-2025953)
0.499
2
UniProt:Q15532 SS18
1
SS18 [nucleoplasm]
(R-HSA-9727441)
0.499
2
UniProt:Q04724 TLE1
2
Ub-TLE1 [nucleoplasm]
(R-HSA-3322369)
TLE1 [nucleoplasm]
(R-HSA-212327)
0.462
10
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