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IKK related kinases TBK1/IKK epsilon
Stable Identifier
R-HSA-450329
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
TAX1BP1:TNFAIP3:TBK1/IKKi [cytosol] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Recruitment of IRF3,IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
TBK1/IKKi:SIKE1 [cytosol] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Recruitment of IRF7 to TRAF6 (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi:IRF7 [mitochondrial outer membrane] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
TBK1/IKKi:SIKE1 [cytosol] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane] (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
IKK related kinases TBK1/IKK epsilon [cytosol] (Homo sapiens)
Participants
members
IKBKE [cytosol] (Homo sapiens)
TBK1 [cytosol] (Homo sapiens)
Participant Of
input
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
hasComponent
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKKi [mitochondrial outer membrane]
TAX1BP1:TNFAIP3:TBK1/IKKi [cytosol]
TBK1/IKKi:SIKE1 [cytosol]
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
Inferred To
IKK related kinases TBK1/IKK epsilon [cytosol] (Bos taurus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Canis familiaris)
IKK related kinases TBK1/IKK epsilon [cytosol] (Danio rerio)
IKK related kinases TBK1/IKK epsilon [cytosol] (Drosophila melanogaster)
IKK related kinases TBK1/IKK epsilon [cytosol] (Gallus gallus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Mus musculus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Plasmodium falciparum)
IKK related kinases TBK1/IKK epsilon [cytosol] (Rattus norvegicus)
IKK related kinases TBK1/IKK epsilon [cytosol] (Sus scrofa)
IKK related kinases TBK1/IKK epsilon [cytosol] (Taeniopygia guttata)
IKK related kinases TBK1/IKK epsilon [cytosol] (Xenopus tropicalis)
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