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TBK1, IKBKE [cytosol]
Stable Identifier
R-HSA-450329
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
IKK related kinases TBK1/IKK epsilon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 M protein interacts with TBK1/IKBKE (Homo sapiens)
M:TBK1, IKBKE [Golgi membrane] (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)
TAX1BP1:TNFAIP3:TBK1/IKKi [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
TBK1 or IKBKE forms homodimers (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Phosphorylation and release of IRF7 (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
TBK1, IKBKE form homodimers (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TBK1, IKBKE [cytosol] (Homo sapiens)
Participants
members
IKBKE [cytosol]
(Homo sapiens)
TBK1 [cytosol]
(Homo sapiens)
Participates
as an input of
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation (Homo sapiens)
TBK1, IKBKE form homodimers (Homo sapiens)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)
TBK1 or IKBKE forms homodimers (Homo sapiens)
as a component of
dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TAX1BP1:TNFAIP3:TBK1/IKKi [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:TBK1/IKBKE [mitochondrial outer membrane] (Homo sapiens)
TBK1/IKBKE:SIKE1 [cytosol] (Homo sapiens)
Inferred To
TBK1, IKBKE [cytosol]
(Bos taurus)
TBK1, IKBKE [cytosol]
(Canis familiaris)
TBK1, IKBKE [cytosol]
(Danio rerio)
TBK1, IKBKE [cytosol]
(Drosophila melanogaster)
TBK1, IKBKE [cytosol]
(Gallus gallus)
TBK1, IKBKE [cytosol]
(Mus musculus)
TBK1, IKBKE [cytosol]
(Rattus norvegicus)
TBK1, IKBKE [cytosol]
(Sus scrofa)
TBK1, IKBKE [cytosol]
(Xenopus tropicalis)
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