Reactome | p-S63,S73-JUN [nucleoplasm]

p-S63,S73-JUN [nucleoplasm]

Stable Identifier

R-HSA-450237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S63,S73-c-Jun, Transcription factor AP-1 (phosphorylated)

Icon

Locations in the PathwayBrowser for interactor UniProt:P20042 EIF2S2

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External Reference Information

External Reference

UniProt:P05412 JUN

Gene Names

JUN

Chain

chain:1-331

Reference Genes

BioGPS Gene:3725 JUN

COSMIC (genes):JUN JUN

CTD Gene:3725 JUN

dbSNP Gene:3725 JUN

ENSEMBL:ENSG00000177606 JUN

ENSEMBL_homo_sapiens_GENE:ENSG00000177606.9 JUN

HGNC:6204 JUN

KEGG Gene (Homo sapiens):3725 JUN

Monarch:3725 JUN

NCBI Gene:3725 JUN

OMIM:165160 JUN

UCSC:P05412 JUN

Reference Transcript

RefSeq:NM_002228.3 JUN

Other Identifiers

11718394_at

11718395_s_at

11718396_x_at

11718397_s_at

16687875

201464_PM_x_at

201464_x_at

201465_PM_s_at

201465_s_at

201466_PM_s_at

201466_s_at

2415046

2415049

2415085

2415086

2415087

2415088

2415089

2415090

2415091

2415092

2415093

2415094

2415095

2415096

2415097

2415098

2415099

2415100

2415101

2415102

2415105

32583_at

3725

7916609

89913_s_at

A_23_P201538

A_33_P3323298

GE57500

GO:0000122

GO:0000228

GO:0000785

GO:0000791

GO:0000976

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0003677

GO:0003690

GO:0003700

GO:0003723

GO:0005096

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0007179

GO:0012501

GO:0019046

GO:0019899

GO:0023052

GO:0031625

GO:0034614

GO:0034976

GO:0035497

GO:0035976

GO:0042127

GO:0042802

GO:0043065

GO:0043226

GO:0043392

GO:0043922

GO:0043923

GO:0044389

GO:0045892

GO:0045893

GO:0045944

GO:0051726

GO:0060395

GO:0061629

GO:0070412

GO:0071276

GO:0090575

GO:0098772

GO:0140110

GO:0140296

GO:0140467

GO:1902895

GO:1904707

GO:1990837

GO:2000144

HMNXSV003055749

Hs.78465.0.S2_3p_a_at

ILMN_1806023

PH_hs_0004525

TC01002708.hg

g12803622_3p_s_at

g7710122_3p_a_at

Participates

as an output of

as an input of

as a component of

This entity regulates

Negatively

NPM1-ALK- and JUN-dependent CDKN1A gene repression (Homo sapiens)

Other forms of this molecule

p-S63,S73-JUN [cytosol]

JUN [nucleoplasm]

JUN [cytosol]

Inferred To

phospho-jun [nucleoplasm] (Danio rerio)

phospho-jun [nucleoplasm] (Xenopus tropicalis)

phospho-JUN [nucleoplasm] (Bos taurus)

phospho-JUN [nucleoplasm] (Canis familiaris)

phospho-JUN [nucleoplasm] (Sus scrofa)

phospho-Jra [nucleoplasm] (Drosophila melanogaster)

phospho-GCN4 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-jun-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-Jun [nucleoplasm] (Mus musculus)

phospho-Jun [nucleoplasm] (Rattus norvegicus)

phospho-p-S63,S73-JUN [nucleoplasm] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 63

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 73

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002219.1

OpenTargets

ENSG00000177606

ZINC - Substances

JUN_HUMAN

ZINC target

P05412

ZINC - Biogenic

JUN_HUMAN

PRO

P05412

PDB

5T01, 1S9K, 5FV8, 1JUN, 1JNM, 1FOS, 6Y3V, 1T2K, 8SOS, 1A02

ZINC - Investigational

JUN_HUMAN

ZINC - Metabolites

JUN_HUMAN

GeneCards

P05412

HPA

ENSG00000177606-JUN

Ensembl

ENSG00000177606, ENST00000371222, ENST00000678696, ENSP00000503132, ENSP00000360266

Pharos - Targets

P05412

ZINC - Predictions - Purchasable

JUN_HUMAN

HMDB Protein

HMDBP02090

Interactors (104)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.975	44
UniProt:P15336 ATF2	2	ATF2 [nucleoplasm] (R-HSA-450336) p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243)	0.95	22
UniProt:P15408 FOSL2			0.899	13
UniProt:Q9NR55 BATF3			0.87	10
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.854	5
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.85	10
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.806	12
UniProt:P53779 MAPK10	3	MAPK10 [cytosol] (R-HSA-450352) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311)	0.755	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.743	6
UniProt:P17544 ATF7			0.723	7
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439)	0.708	5
UniProt:Q02930 CREB5			0.69	7
UniProt:P53539 FOSB	1	FOSB [nucleoplasm] (R-HSA-9009922)	0.69	7
UniProt:Q8WYK2 JDP2			0.69	5
IntAct:EBI-10041487 MMP1			0.688	4
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.683	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.678	4
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.675	5
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.675	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.669	5
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.666	5
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.666	5
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.666	4
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.666	5
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.643	4
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.643	3
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.643	4
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.632	4
UniProt:Q16520 BATF	1	BATF [nucleoplasm] (R-HSA-6789925)	0.623	4
UniProt:Q8WQG9	9	MAPK8 [cytosol] (R-CEL-168141) MAPK10 [cytosol] (R-CEL-450352-3) MAPK9 [cytosol] (R-CEL-450355-3) phospho-p-T183,Y185-MAPK9 [cytosol] (R-CEL-450293-3) phospho-p-T,Y-MAPK8 [cytosol] (R-CEL-194371) phospho-p-T221,Y223-MAPK10 [cytosol] (R-CEL-450214-3) phospho-p-T,Y-MAPK8 [nucleoplasm] (R-CEL-216349) phospho-p-T183,Y185-MAPK9 [nucleoplasm] (R-CEL-450319-3) phospho-p-T221,Y223-MAPK10 [nucleoplasm] (R-CEL-450311-3)	0.623	3
UniProt:O95644 NFATC1	3	p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935) p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-12S-NFATC1 [cytosol] (R-HSA-2025953)	0.612	5
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.597	4
UniProt:Q00005 2ABB			0.597	3
UniProt:P03129 VE7			0.593	4
UniProt:Q13469-2 NFATC2			0.591	6
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.59	4
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.59	2
UniProt:Q8N1L9-1 BATF2			0.581	3
IntAct:EBI-10041770 MMP1			0.577	5
UniProt:Q06481 APLP2	4	APLP2 [endoplasmic reticulum lumen] (R-HSA-8956784) p-APLP2 [endoplasmic reticulum lumen] (R-HSA-8956977) APLP2 [platelet alpha granule membrane] (R-HSA-8848898) APLP2 [plasma membrane] (R-HSA-8848902)	0.573	3
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.564	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.564	3
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.564	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.564	3
UniProt:P07197 NFM			0.564	2
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.564	3
UniProt:P0C746 HBZ			0.558	3
UniProt:Q9DGW5 MEQ			0.558	3
UniProt:Q8WTV0 SCARB1			0.556	3
UniProt:P78563 ADARB1	1	ADARB1 [nucleoplasm] (R-HSA-62915)	0.556	3
IntAct:EBI-25872354 ORF			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.547	2
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.544	2
IntAct:EBI-5590876 TFF1			0.527	2
IntAct:EBI-2677274 MMP9			0.527	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.527	3
UniProt:Q96F63 CCD97			0.527	2
UniProt:O95273 CCDB1			0.527	2
UniProt:Q05D60 DEUP1			0.527	2
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.527	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	3
UniProt:Q02930-2 CREB5			0.527	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	3
UniProt:O75596 CLC3A			0.527	2
UniProt:P55198 AF17			0.527	2
UniProt:P56671 MAZ			0.525	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.524	3
UniProt:P48634 PRC2A			0.524	2
UniProt:Q99966 CITED1	1	CITED1 [nucleoplasm] (R-HSA-8864301)	0.524	2
UniProt:Q9UPY8 MARE3			0.524	3
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.524	4
UniProt:Q8IWZ6 BBS7	1	BBS7 [cytosol] (R-HSA-5617632)	0.524	3
UniProt:P56279 TCL1A			0.524	6
UniProt:Q9NRL3 STRN4			0.524	3
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.524	3
IntAct:EBI-10042615 VGF			0.499	2
UniProt:P18846 ATF1	2	ATF1 [nucleoplasm] (R-HSA-199900) p-S63-ATF1 [nucleoplasm] (R-HSA-199897)	0.499	2
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.483	2
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.462	2
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.462	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.462	2
UniProt:P35453 HXD13			0.462	2
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.462	2
UniProt:Q29RF7 PDS5A	4	PDS5A [cytosol] (R-HSA-2484799) PDS5A [chromosome] (R-HSA-2466360) PDS5A [chromosome, centromeric region] (R-HSA-2468259) PDS5A [nucleoplasm] (R-HSA-2468043)	0.462	2
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.462	2
UniProt:P17482 HXB9			0.462	2
UniProt:Q02078 MEF2A	3	p-T312,T319-MEF2A [nucleoplasm] (R-HSA-448834) p-S408-MEF2A [nucleoplasm] (R-HSA-199909) MEF2A [nucleoplasm] (R-HSA-199903)	0.462	4
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.462	4
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.462	2
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.462	4
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.462	3
UniProt:O15226 NKRF			0.462	2
UniProt:P41252 IARS1	1	IARS [cytosol] (R-HSA-379641)	0.462	3
UniProt:Q92945 KHSRP	4	p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.462	3
IntAct:EBI-10041773 MMP1			0.462	3
UniProt:P16220 CREB1			0.462	3
UniProt:P49916 LIG3	1	LIG3 [nucleoplasm] (R-HSA-53789)	0.462	3
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.462	2

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