Reactome | GRIK5 [plasma membrane]

GRIK5 [plasma membrane]

Stable Identifier

R-HSA-450197

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Glutamate receptor, ionotropic kainate 5, GRIK5_HUMAN, KA2

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of kainate receptors upon glutamate binding (Homo sapiens)
      - Ionotropic activity of kainate receptors (Homo sapiens)
        
        Activation of Ca-permeable Kainate Receptor (Homo sapiens)
        
        Activation of Ca-permeable Kainate receptors (Homo sapiens)
        
        Kainate receptor-glutamate complex [plasma membrane] (Homo sapiens)
        
        Kainate Receptors [plasma membrane] (Homo sapiens)
        
        GRIK5 heteromer with GRIk1/2/3 [plasma membrane] (Homo sapiens)
        
        GRIK5 [plasma membrane] (Homo sapiens)
        
        kainate receptor binds glutamate (Homo sapiens)
        
        Kainate Receptors [plasma membrane] (Homo sapiens)
        
        GRIK5 heteromer with GRIk1/2/3 [plasma membrane] (Homo sapiens)
        
        GRIK5 [plasma membrane] (Homo sapiens)
        
        Kainate receptor-glutamate complex [plasma membrane] (Homo sapiens)
        
        Kainate Receptors [plasma membrane] (Homo sapiens)
        
        GRIK5 heteromer with GRIk1/2/3 [plasma membrane] (Homo sapiens)
        
        GRIK5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16478 GRIK5

Gene Names

GRIK5, GRIK2

Chain

signal peptide:1-14, chain:15-980

Reference Genes

BioGPS Gene:2901 GRIK5

COSMIC (genes):GRIK5 GRIK5

CTD Gene:2901 GRIK5

dbSNP Gene:2901 GRIK5

ENSEMBL:ENSG00000105737.10 GRIK5

HGNC:4583 GRIK5

KEGG Gene (Homo sapiens):2901 GRIK5

Monarch:2901 GRIK5

NCBI Gene:2901 GRIK5

OMIM:600283 GRIK5

UCSC:Q16478 GRIK5

Reference Transcript

Other Identifiers

0001660450

11755672_a_at

1553168_PM_at

1553168_at

16872682

214966_3p_at

214966_PM_at

214966_at

217509_3p_x_at

217509_PM_x_at

217509_x_at

2901

34904_at

34905_at

34906_g_at

3863381

3863382

3863383

3863384

3863385

3863386

3863387

3863388

3863389

3863390

3863391

3863393

3863394

3863399

3863400

3863401

3863402

3863408

3863410

3863412

3863413

3863414

3863415

3863416

3863418

3863419

3863421

3863422

3863426

3863427

3863428

8037103

A_23_P16063

GE62972

GO:0004970

GO:0005215

GO:0005216

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005886

GO:0006621

GO:0006811

GO:0007215

GO:0007268

GO:0008066

GO:0008328

GO:0012501

GO:0014069

GO:0015276

GO:0015277

GO:0016020

GO:0016021

GO:0016192

GO:0017124

GO:0023052

GO:0030165

GO:0030424

GO:0030425

GO:0031630

GO:0032983

GO:0032991

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0042391

GO:0042734

GO:0042802

GO:0043005

GO:0043025

GO:0043113

GO:0043195

GO:0043204

GO:0043226

GO:0043525

GO:0045202

GO:0045211

GO:0050804

GO:0050877

GO:0051649

GO:0055085

GO:0060079

GO:0060089

GO:0061024

GO:0071333

GO:0098686

GO:0098978

GO:0099055

GO:0099056

GO:0099061

GO:0110165

GO:1904315

HMNXSV003046543

HMNXSV003047154

Hs.128095.0.A1_3p_at

Hs.128095.0.A1_3p_x_at

Hs.249141.0.A1_3p_at

Hs.249141.0.A1_3p_s_at

Hs2.249141.1.S1_3p_at

ILMN_1679595

PH_hs_0040813

TC19001564.hg

Participates

as a component of

GRIK5 heteromer with GRIk1/2/3 [plasma membrane] (Homo sapiens)

Inferred To

glr-4 [plasma membrane] (Caenorhabditis elegans)

GluRIIA [plasma membrane] (Drosophila melanogaster)

Homologues of GRIK5 [plasma membrane] (Caenorhabditis elegans)

Homologues of GRIK5 [plasma membrane] (Drosophila melanogaster)

Ekar [plasma membrane] (Drosophila melanogaster)

GluRIIE [plasma membrane] (Drosophila melanogaster)

Ir21a [plasma membrane] (Drosophila melanogaster)

Ir75d [plasma membrane] (Drosophila melanogaster)

GluRIID [plasma membrane] (Drosophila melanogaster)

Grik5 [plasma membrane] (Mus musculus)

Grik5 [plasma membrane] (Rattus norvegicus)

DmelCG11155 [plasma membrane] (Drosophila melanogaster)

Grik [plasma membrane] (Drosophila melanogaster)

GluRIIC [plasma membrane] (Drosophila melanogaster)

glr-6 [plasma membrane] (Caenorhabditis elegans)

grik5 [plasma membrane] (Xenopus tropicalis)

glr-5 [plasma membrane] (Caenorhabditis elegans)

GRIK5 [plasma membrane] (Bos taurus)

GRIK5 [plasma membrane] (Caenorhabditis elegans)

GRIK5 [plasma membrane] (Canis familiaris)

GRIK5 [plasma membrane] (Danio rerio)

GRIK5 [plasma membrane] (Drosophila melanogaster)

GRIK5 [plasma membrane] (Sus scrofa)

clumsy [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_002079.3, XP_011525165.1, NP_001287959.1, XP_005258878.1

ZINC - World Drugs

GRIK5_HUMAN

Guide to Pharmacology - Targets

454

OpenTargets

ENSG00000105737

ZINC - FDA approved

GRIK5_HUMAN

ZINC - Substances

GRIK5_HUMAN

ZINC target

Q16478

ZINC - Biogenic

GRIK5_HUMAN

PRO

Q16478

ZINC - Metabolites

GRIK5_HUMAN

HPA

ENSG00000105737-GRIK5

GeneCards

Q16478

Ensembl

ENST00000301218, ENST00000593562, ENSG00000105737, ENSP00000301218, ENSP00000262895, ENSP00000470251, ENST00000262895

Pharos - Targets

Q16478

ZINC - Predictions - Purchasable

GRIK5_HUMAN