IRAK1 induces oligomerisation of TRAF6

Stable Identifier
R-HSA-450173
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

TRAF6 oligomerization is induced by IRAK1. The TRAF6 oligomer consists of more than two molecules of TRAF6; thermodynamic data for TRAF2 strongly suggests that it is functionally a trimer (Rawlings et al. 2006). TRAF6 is represented here as a trimer, though the extent and significance of TRAF6 oligomerization is unclear. Oligomerisation may be assisted by TIFA (TRAF-interacting protein with a FHA domain; Takatsuna et al. 2003).

Literature References
PubMed ID Title Journal Year
18070982 TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB

Muroi, M, Tanamoto, K

J Leukoc Biol 2008
Participants
Participant Of
Orthologous Events
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Reviewed