IL1R1:IL1:IL1RAP binds MYD88 homodimer

Stable Identifier
R-HSA-450133
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MYD88 is a cytoplasmic adaptor protein that is recruited to the intracellular region of the IL1 receptor complex following IL1 stimulation. MYD88 binds to the complex of the two receptor chains and subsequently to IL-1 receptor-associated kinase 4 (IRAK4). This complex is the minimum required for signaling (Brikos et al. 2007).

Literature References
PubMed ID Title Journal Year
17507369 Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components

Brikos, C, Wait, R, Begum, S, O'Neill, LA, Saklatvala, J

Mol Cell Proteomics 2007
9430229 MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

Wesche, H, Henzel, WJ, Shillinglaw, W, Li, S, Cao, Z

Immunity 1997
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