Reactome | IL1R1:IL1:IL1RAP binds MYD88 homodimer

IL1R1:IL1:IL1RAP binds MYD88 homodimer

Stable Identifier

R-HSA-450133

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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MYD88 is a cytoplasmic adaptor protein that is recruited to the intracellular region of the IL1 receptor complex following IL1 stimulation. MYD88 binds to the complex of the two receptor chains and subsequently to IL-1 receptor-associated kinase 4 (IRAK4). This complex is the minimum required for signaling (Brikos et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
9430229	MyD88: an adapter that recruits IRAK to the IL-1 receptor complex Henzel, WJ, Wesche, H, Li, S, Cao, Z, Shillinglaw, W	Immunity	1997
17507369	Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components Begum, S, Brikos, C, O'Neill, LA, Wait, R, Saklatvala, J	Mol Cell Proteomics	2007