Reactome | GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region

GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region

Stable Identifier

R-HSA-450095

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

Synonyms

alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular), Glucose is secreted across the plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GLUT2 (glucose transporter) homotetramers associated with the plasma membrane mediate the facilitated diffusion of glucose between the cytosol and the extracellular space, so glucose will leave cells when its intracellular concentration exceeds the extracellular one (Colville et al. 1993; Santer et al. 1997; Wu et al. 1998). In the body, such glucose export is a normal feature of liver cells when gluconeogenesis or glycogen breakdown is underway.

Literature References

PubMed ID	Title	Journal	Year
8457197	Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM	Biochem J	1993
9751501	Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity Wu, L, Fritz, JD, Powers, AC	Endocrinology	1998
9354798	Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome Santer, R, Schneppenheim, R, Dombrowski, A, Gotze, H, Steinmann, B, Schaub, J	Nat Genet	1997