GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
alpha-D-glucose (cytosol) <=> alpha-D-glucose (extracellular), Glucose is secreted across the plasma membrane
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GLUT2 (glucose transporter) homotetramers associated with the plasma membrane mediate the facilitated diffusion of glucose between the cytosol and the extracellular space, so glucose will leave cells when its intracellular concentration exceeds the extracellular one (Colville et al. 1993; Santer et al. 1997; Wu et al. 1998). In the body, such glucose export is a normal feature of liver cells when gluconeogenesis or glycogen breakdown is underway.

Literature References
PubMed ID Title Journal Year
9354798 Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome

Santer, R, Dombrowski, A, Steinmann, B, Gotze, H, Schaub, J, Schneppenheim, R

Nat Genet 1997
9751501 Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity

Powers, AC, Wu, L, Fritz, JD

Endocrinology 1998
8457197 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

Gould, GW, Colville, CA, Seatter, MJ, Thomas, HM, Jess, TJ

Biochem J 1993
Catalyst Activity

D-glucose transmembrane transporter activity of GLUT2 / SLC2A2 tetramer [plasma membrane]

Orthologous Events
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