Interleukin-3 receptor alpha subunit binds Interleukin-3

Stable Identifier
R-HSA-450074
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Interleukin-3 receptor alpha subunit binds Interleukin-3
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The Interleukin-3 receptor alpha subunit (IL3Ra) has a single transmembrane domain, a glycosylated extracellular domain and a short (53 amino acids) cytoplasmic tail, containing no tyrosine kinase domain (Kitamura et al. 1991). It binds interleukin-3 with low affinity, and is not capable of signaling by itself.
Literature References
PubMed ID Title Journal Year
1833064 Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

Arai, K, Miyajima, A, Sato, N, Kitamura, T

Cell 1991
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as an event of
Orthologous Events
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Bos taurus)
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Rattus norvegicus)
Authored
Ray, KP  (2010-05-17)
Reviewed
Hercus, TR  (2010-09-06)
Lopez, AF  (2010-09-06)
Created
Jupe, S  (2009-12-11)
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