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IL3 [extracellular region]
Stable Identifier
R-HSA-450059
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-3, IL3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P32927 CSF2RB
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in interleukin signaling (Homo sapiens)
IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)
IL3 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
IL3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08700 IL3
Gene Names
IL3
Chain
signal peptide:1-19, chain:20-152
Reference Genes
BioGPS Gene:3562 IL3
COSMIC (genes):IL3 IL3
CTD Gene:3562 IL3
dbSNP Gene:3562 IL3
ENSEMBL:ENSG00000164399 IL3
ENSEMBL_homo_sapiens_GENE:ENSG00000164399.5 IL3
HGNC:6011 IL3
KEGG Gene (Homo sapiens):3562 IL3
Monarch:3562 IL3
NCBI Gene:3562 IL3
OMIM:147740 IL3
UCSC:P08700 IL3
Reference Transcript
RefSeq:NM_000588.3 IL3
Other Identifiers
11732963_at
1263_at
16988964
207906_PM_at
207906_at
2828324
2828325
2828326
2828327
2828329
2828331
2828332
2828333
2828335
3562
8107878
A_14_P110601
A_23_P348831
A_33_P3419264
GE533942
GO:0002376
GO:0005125
GO:0005135
GO:0005515
GO:0005576
GO:0005615
GO:0006955
GO:0007267
GO:0007399
GO:0008083
GO:0008284
GO:0023052
GO:0030154
GO:0035162
GO:0036211
GO:0038156
GO:0042531
GO:0048018
GO:0048856
GO:0050731
GO:0098772
HMNXSV003054020
ILMN_1766320
M20137_at
PH_hs_0000079
TC05000628.hg
g4504666_3p_at
Participates
as an output of
IL3 gene transcription is stimulated by RUNX1 and ELF1 (Homo sapiens)
as an input of
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
as a component of
IL3:IL3RA [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of IL3 [extracellular region]
(Gallus gallus)
Il3 [extracellular region]
(Mus musculus)
Il3 [extracellular region]
(Rattus norvegicus)
IL3 [extracellular region]
(Bos taurus)
IL3 [extracellular region]
(Canis familiaris)
Cross References
RefSeq
NP_000579.2
OpenTargets
ENSG00000164399
HPA
ENSG00000164399-IL3
GeneCards
P08700
Ensembl
ENSG00000164399
,
ENST00000296870
,
ENSP00000296870
PRO
P08700
Pharos - Targets
P08700
HMDB Protein
HMDBP02287
PDB
1JLI
,
5UV8
,
6NMY
,
5UWC
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26951-1 IL3RA
0.611
5
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.589
2
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