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What is Reactome ?
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IL3:IL3RA [plasma membrane]
Stable Identifier
R-HSA-450048
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Activation of STAT5a/b by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3RB is phosphorylated on Ser-585 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2, phosphorylated Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
JAK2 is phosphorylated, activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, p(Y593)-Bc [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
STAT5 is recruited by JAK2 (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
The receptor is activated (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Tyrosine kinases phosphorylate the receptor (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Homo sapiens)
High affinity IL-3 receptor complex dimer, inactive JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from the receptor complex (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, activated JAK2:p-STAT5 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Homo sapiens)
IL3:IL3R active complex, JAK2:p-Y593,Y629-IL3RB [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA [plasma membrane] (Homo sapiens)
Participants
components
IL3 [extracellular region]
(Homo sapiens)
IL3RA [plasma membrane]
(Homo sapiens)
Participates
as a component of
IL3RA:IL3:p(Y593)-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:pS585-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3RA:IL3:p(Y593)-IL3RB:Activated JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:IL3RB:p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
IL3:IL3RA:p-Y593,Y628-IL3RB:JAK2 [plasma membrane] (Homo sapiens)
as an output of
Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)
as an input of
Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Homo sapiens)
Inferred To
IL3:IL3RA [plasma membrane]
(Bos taurus)
IL3:IL3RA [plasma membrane]
(Canis familiaris)
IL3:IL3RA [plasma membrane]
(Gallus gallus)
IL3:IL3RA [plasma membrane]
(Mus musculus)
IL3:IL3RA [plasma membrane]
(Rattus norvegicus)
© 2025
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