Reactome | IL2RA [plasma membrane]

IL2RA [plasma membrane]

Stable Identifier

R-HSA-450046

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-2 receptor alpha chain, IL2RA_HUMAN, CD25

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Locations in the PathwayBrowser for interactor UniProt:P60568 IL2

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External Reference Information

External Reference

UniProt:P01589 IL2RA

Gene Names

IL2RA

Chain

signal peptide:1-21, chain:22-272

Reference Genes

BioGPS Gene:3559 IL2RA

COSMIC (genes):IL2RA IL2RA

CTD Gene:3559 IL2RA

dbSNP Gene:3559 IL2RA

ENSEMBL:ENSG00000134460 IL2RA

HGNC:6008 IL2RA

KEGG Gene (Homo sapiens):3559 IL2RA

Monarch:3559 IL2RA

NCBI Gene:3559 IL2RA

OMIM:147730 IL2RA

UCSC:P01589 IL2RA

Reference Transcript

Other Identifiers

0006900014

11739954_at

11739955_a_at

11752775_a_at

16711501

1702_at

206341_at

211269_s_at

3275730

3275731

3275732

3275733

3275734

3275743

3275746

3275747

3275748

3275751

3275752

3275758

3275759

3275760

3275769

3275770

3275771

3559

77706_at

7931914

A_23_P127288

A_24_P230563

GE59635

GO:0000165

GO:0002376

GO:0002437

GO:0002664

GO:0003674

GO:0004911

GO:0005515

GO:0005575

GO:0005886

GO:0005893

GO:0006464

GO:0006915

GO:0006924

GO:0006950

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0007219

GO:0008150

GO:0008219

GO:0008283

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0019221

GO:0019976

GO:0030154

GO:0032991

GO:0038110

GO:0042102

GO:0042104

GO:0042130

GO:0042592

GO:0043029

GO:0045582

GO:0045589

GO:0046013

GO:0048856

GO:0050672

GO:0050728

HMNXSV003043253

ILMN_1683774

ILMN_2108699

PH_hs_0022432

TC10001007.hg

X01057_at

g186319_3p_a_at

Participates

as an output of

IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)

as an input of

Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)

as a component of

Inferred To

IL2RA [plasma membrane] (Bos taurus)

IL2RA [plasma membrane] (Gallus gallus)

Il2ra [plasma membrane] (Mus musculus)

Il2ra [plasma membrane] (Rattus norvegicus)

Ghost homologue of IL2RA [plasma membrane] (Canis familiaris)

Ghost homologue of IL2RA [plasma membrane] (Danio rerio)

Ghost homologue of IL2RA [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001295172.1, NP_001295171.1, NP_000408.1

Guide to Pharmacology - Targets

1695

OpenTargets

ENSG00000134460

ZINC - Substances

IL2RA_HUMAN

ZINC target

P01589

PRO

P01589

GlyGen

P01589

PDB

6VWU, 1ILN, 6YIO, 2ERJ, 1ILM, 3IU3, 2B5I, 1Z92, 3NFP

GeneCards

P01589

HPA

ENSG00000134460-IL2RA

Ensembl

ENSP00000369293, ENSG00000134460, ENST00000379959

Pharos - Targets

P01589

ZINC - Predictions - Purchasable

IL2RA_HUMAN

Orphanet

17467

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60568 IL2	1	IL2 [extracellular region] (R-HSA-447099)	0.667	3