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IL2RA [plasma membrane]
Stable Identifier
R-HSA-450046
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-2 receptor alpha chain, IL2RA_HUMAN, CD25
Icon
Locations in the PathwayBrowser for interactor UniProt:P60568 IL2
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)
IL2RA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01589 IL2RA
Gene Names
IL2RA
Chain
signal peptide:1-21, chain:22-272
Reference Genes
BioGPS Gene:3559 IL2RA
COSMIC (genes):IL2RA IL2RA
CTD Gene:3559 IL2RA
dbSNP Gene:3559 IL2RA
ENSEMBL:ENSG00000134460 IL2RA
HGNC:6008 IL2RA
KEGG Gene (Homo sapiens):3559 IL2RA
Monarch:3559 IL2RA
NCBI Gene:3559 IL2RA
OMIM:147730 IL2RA
UCSC:P01589 IL2RA
Reference Transcript
RefSeq:NM_000417.2 IL2RA
RefSeq:NM_001308243.1 IL2RA
RefSeq:NM_001308242.1 IL2RA
Other Identifiers
0006900014
11739954_at
11739955_a_at
11752775_a_at
16711501
1702_at
206341_at
211269_s_at
3275730
3275731
3275732
3275733
3275734
3275743
3275746
3275747
3275748
3275751
3275752
3275758
3275759
3275760
3275769
3275770
3275771
3559
77706_at
7931914
A_23_P127288
A_24_P230563
GE59635
GO:0000165
GO:0002376
GO:0002437
GO:0002664
GO:0003674
GO:0004911
GO:0005515
GO:0005575
GO:0005886
GO:0005893
GO:0006464
GO:0006915
GO:0006924
GO:0006950
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0007219
GO:0008150
GO:0008219
GO:0008283
GO:0009897
GO:0009986
GO:0016020
GO:0016021
GO:0019221
GO:0019976
GO:0030154
GO:0032991
GO:0038110
GO:0042102
GO:0042104
GO:0042130
GO:0042592
GO:0043029
GO:0045582
GO:0045589
GO:0046013
GO:0048856
GO:0050672
GO:0050687
GO:0050728
GO:0050777
ILMN_1683774
ILMN_2108699
PH_hs_0022432
TC10001007.hg
X01057_at
g186319_3p_a_at
Participant Of
output
IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1
input
Interleukin-2 receptor alpha binds interleukin-2
hasComponent
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]
IL2:IL2RA [plasma membrane]
IL2RA:IL2RB:p-JAK1 [plasma membrane]
Inferred To
IL2RA [plasma membrane] (Bos taurus)
IL2RA [plasma membrane] (Gallus gallus)
Il2ra [plasma membrane] (Mus musculus)
Il2ra [plasma membrane] (Rattus norvegicus)
Ghost homologue of IL2RA [plasma membrane] (Canis familiaris)
Ghost homologue of IL2RA [plasma membrane] (Danio rerio)
Ghost homologue of IL2RA [plasma membrane] (Sus scrofa)
Ghost homologue of IL2RA [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_001295171.1
,
NP_001295172.1
,
NP_000408.1
OpenTargets
ENSG00000134460
ZINC - Substances
IL2RA_HUMAN
GeneCards
P01589
HPA
ENSG00000134460-IL2RA
Ensembl
ENST00000379959
,
ENSP00000369293
,
ENSG00000134460
ZINC target
P01589
PRO
P01589
Orphanet
17467
ZINC - Predictions - Purchasable
IL2RA_HUMAN
PDB
1Z92
,
3IU3
,
6VWU
,
1ILN
,
1ILM
,
2ERJ
,
2B5I
,
3NFP
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60568 IL2
1
IL2 [extracellular region]
(R-HSA-447099)
0.667
3
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