IL7:IL7R:JAK1 binds IL2RG:JAK3

Stable Identifier
R-HSA-449958
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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IL7:IL7R:JAK1 binds IL2RG:JAK3
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Studies using chemical crosslinking and monoclonal antibodies specific for Cytokine receptor common subunit gamma (IL2RG) demonstrated that it participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994).
IL2RG interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds Interleukin-7 (IL7) with a 3-fold higher affinity (Kd =80 pM).

Literature References
PubMed ID Title Journal Year
8266077 Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

Noguchi, M, Nakamura, Y, Russell, SM, Ziegler, SF, Tsang, M, Cao, X, Leonard, WJ

Science 1993
8128231 Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

Kondo, M, Takeshita, T, Higuchi, M, Nakamura, M, Sudo, T, Nishikawa, S, Sugamura, K

Science 1994
Participants
Input
Output
Participant Of
hasEvent
Authored
Ray, KP  (2010-05-17)
Reviewed
Puck, J  (2011-11-03)
Created
Jupe, S  (2009-12-11)