Studies using chemical crosslinking and monoclonal antibodies specific for Cytokine receptor common subunit gamma (IL2RG) demonstrated that it participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). IL2RG interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds Interleukin-7 (IL7) with a 3-fold higher affinity (Kd =80 pM).
Noguchi, M, Nakamura, Y, Russell, SM, Ziegler, SF, Tsang, M, Cao, X, Leonard, WJ
Kondo, M, Takeshita, T, Higuchi, M, Nakamura, M, Sudo, T, Nishikawa, S, Sugamura, K
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