Studies using chemical crosslinking and monoclonal antibodies specific for Cytokine receptor common subunit gamma (IL2RG) demonstrated that it participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994). IL2RG interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds Interleukin-7 (IL7) with a 3-fold higher affinity (Kd =80 pM).
Takeshita, T, Higuchi, M, Sugamura, K, Sudo, T, Kondo, M, Nishikawa, S, Nakamura, M
Tsang, M, Cao, X, Ziegler, SF, Russell, SM, Noguchi, M, Nakamura, Y, Leonard, WJ
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