acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

Stable Identifier
R-HSA-449911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]
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ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).
Literature References
PubMed ID Title Journal Year
16788062 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B, Verdin, RO, Andersen, JS, Verdin, E, Bunkenborg, J

Proc Natl Acad Sci U S A 2006
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Output
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as an event of
Catalyst Activity

acetate-CoA ligase activity of ACSS1 [mitochondrial matrix]

Physical Entity
ACSS1 [mitochondrial matrix] (Homo sapiens)
Activity
acetate-CoA ligase activity (GO:0003987)
Orthologous Events
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Canis familiaris)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Gallus gallus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Saccharomyces cerevisiae)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)
acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-12-09)
Reviewed
Jassal, B  (2010-02-27)
Created
D'Eustachio, P  (2009-12-09)
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