acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]

Stable Identifier
R-HSA-449911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ACSS1 (acyl-CoA synthetase short-chain family member 1) in the mitochondrial matrix catalyzes the reaction of acetate, coenzyme A, and ATP to form acetyl-CoA, AMP, and pyrophosphate (Schwer et al. 2006).

Literature References
PubMed ID Title Journal Year
16788062 Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

Schwer, B, Bunkenborg, J, Verdin, RO, Andersen, JS, Verdin, E

Proc Natl Acad Sci U S A 2006
Participants
Participates
Catalyst Activity

acetate-CoA ligase activity of ACSS1 [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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