Addition of a third mannose to the N-glycan precursor by ALG2

Stable Identifier
R-HSA-449718
Type
Reaction
Species
Homo sapiens
Compartment
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A third mannose is added to the N-glycan precursor by ALG2 using its alpha1,6-mannosyltransferase activity. This has been demonstrated experimentally in yeast (O'Reilly MK et al, 2006; Kämpf M et al, 2009); the human reaction is inferred by homology. Defects in ALG2 are the cause for CDG1I (Thiel C et al, 2003).

Literature References
Participants
Participates
Catalyst Activity

alpha-1,6-mannosyltransferase activity of ALG2 [endoplasmic reticulum membrane]

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