A third mannose is added to the N-glycan precursor by ALG2 using its alpha1,6-mannosyltransferase activity. This has been demonstrated experimentally in yeast (O'Reilly MK et al, 2006; Kämpf M et al, 2009); the human reaction is inferred by homology. Defects in ALG2 are the cause for CDG1I (Thiel C et al, 2003).
O'Reilly, MK, Zhang, G, Imperiali, B
Kämpf, M, Absmanner, B, Schwarz, M, Lehle, L
Thiel, C, Schwarz, M, Peng, J, Grzmil, M, Hasilik, M, Braulke, T, Kohlschütter, A, von Figura, K, Lehle, L, Körner, C
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