Addition of a third mannose to the N-glycan precursor by ALG2

Stable Identifier
R-HSA-449718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
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Addition of a third mannose to the N-glycan precursor by ALG2
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A third mannose is added to the N-glycan precursor by ALG2 using its alpha1,6-mannosyltransferase activity. This has been demonstrated experimentally in yeast (O'Reilly MK et al, 2006; Kämpf M et al, 2009); the human reaction is inferred by homology. Defects in ALG2 are the cause for CDG1I (Thiel C et al, 2003).

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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
alpha-1,6-mannosyltransferase activity of ALG2 [endoplasmic reticulum membrane]
Physical Entity
ALG2 [endoplasmic reticulum membrane]
Activity
alpha-1,6-mannosyltransferase activity (0000009)
Inferred From
Addition of a third mannose to the N-glycan precursor by Alg2 (Saccharomyces cerevisiae)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
Jassal, B  (2009-12-07)