Reactome | DOLPP1 [endoplasmic reticulum membrane]

DOLPP1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-449706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dolichyldiphosphatase 1, DOPP1_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        DOLPP1 dephosphorylates DOLDP to DOLP (Homo sapiens)
        
        DOLPP1 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86YN1 DOLPP1

Gene Names

DOLPP1, LSFR2

Chain

chain:1-238

Reference Genes

BioGPS Gene:57171 DOLPP1

COSMIC (genes):DOLPP1 DOLPP1

CTD Gene:57171 DOLPP1

dbSNP Gene:57171 DOLPP1

ENSEMBL:ENSG00000167130 DOLPP1

ENSEMBL_homo_sapiens_GENE:ENSG00000167130.18 DOLPP1

HGNC:29565 DOLPP1

KEGG Gene (Homo sapiens):57171 DOLPP1

Monarch:57171 DOLPP1

NCBI Gene:57171 DOLPP1

OMIM:614516 DOLPP1

UCSC:Q86YN1 DOLPP1

Reference Transcript

Other Identifiers

11722919_a_at

11722920_s_at

17089982

221817_PM_at

221817_at

3190926

3190927

3190928

3190930

3190931

3190932

3190933

3190934

3190935

3190937

3190938

32929_at

49479_at

57171

8158513

A_14_P111558

A_23_P330017

A_23_P386764

GO:0003824

GO:0005783

GO:0005789

GO:0006486

GO:0006487

GO:0006489

GO:0006629

GO:0008610

GO:0016020

GO:0016787

GO:0036211

GO:0043226

GO:0043231

GO:0044238

GO:0044249

GO:0047874

GO:1901135

GO:1901576

HMNXSV003057853

Hs.21701.0.A1_3p_at

ILMN_1672042

PH_hs_0031059

TC09000707.hg

Inferred To

DOLPP1 [endoplasmic reticulum membrane] (Bos taurus)

DOLPP1 [endoplasmic reticulum membrane] (Canis familiaris)

DOLPP1 [endoplasmic reticulum membrane] (Gallus gallus)

DOLPP1 [endoplasmic reticulum membrane] (Sus scrofa)

Dolpp1 [endoplasmic reticulum membrane] (Mus musculus)

Dolpp1 [endoplasmic reticulum membrane] (Rattus norvegicus)

dolpp1 [endoplasmic reticulum membrane] (Danio rerio)

dolpp1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

dolpp1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

pdf1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_065171.2, NP_001129389.1

OpenTargets

ENSG00000167130

IntEnz

3.6.1.43

GeneCards

Q86YN1

HPA

ENSG00000167130-DOLPP1

Ensembl

ENSP00000361625, ENSP00000384043, ENST00000372546, ENSG00000167130, ENST00000406974

PRO

Q86YN1

Pharos - Targets

Q86YN1

HMDB Protein

HMDBP01590

Interactors (3)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q6MZM0 HPHL1	0.527	2
UniProt:Q86SG7 LYG2	0.527	2
UniProt:P0DPA2 VSIG8	0.527	2

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