Reactome | IL4R [plasma membrane]

IL4R [plasma membrane]

Stable Identifier

R-HSA-449670

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IL4RA, Interleukin-4 receptor alpha chain, IL4RA_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q86XL3 ANKLE2

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External Reference Information

External Reference

UniProt:P24394 IL4R

Gene Names

IL4R, IL4RA, 582J2.1

Chain

signal peptide:1-25, chain:26-825, chain:26-

Reference Genes

BioGPS Gene:3566 IL4R

COSMIC (genes):IL4R IL4R

CTD Gene:3566 IL4R

dbSNP Gene:3566 IL4R

ENSEMBL:ENSG00000077238 IL4R

HGNC:6015 IL4R

KEGG:hsa:3566 IL4R

Monarch:3566 IL4R

NCBI Gene:3566 IL4R

OMIM:147781 IL4R

UCSC:P24394 IL4R

Reference Transcript

Other Identifiers

11718073_at

11718074_a_at

11718075_at

11742511_a_at

11748724_a_at

16817254

203233_PM_at

203233_at

3566

3654176

3654177

3654183

3654184

3654186

3654187

3654188

3654189

3654190

3654191

3654192

3654195

3654196

3654197

3654198

3654199

3654200

3654201

3654202

3654205

3654206

3654207

3654210

3654211

3654212

3654213

3654214

3654215

3654216

3654217

3654218

404_at

7994280

A_23_P129556

A_33_P3349045

A_33_P3395947

GE53990

GE870401

GO:0002376

GO:0002532

GO:0002639

GO:0004896

GO:0004913

GO:0005515

GO:0005576

GO:0005654

GO:0005886

GO:0006955

GO:0007165

GO:0007166

GO:0009897

GO:0016020

GO:0016064

GO:0019221

GO:0030154

GO:0032722

GO:0034451

GO:0035771

GO:0042832

GO:0043032

GO:0043235

GO:0043306

GO:0045063

GO:0045064

GO:0045626

GO:0045630

GO:0060089

GO:0098542

GO:0120162

GO:1901741

HMNXSV003009200

HMNXSV003012450

ILMN_1652185

PH_hs_0004340

TC16000293.hg

X52425_at

g4557668_3p_at

Participates

as a member of

STAT6 upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)

as an input of

IL4R binds JAK2 (Homo sapiens)

as a component of

IL4R:JAK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-IL4R [plasma membrane]

Inferred To

IL4R [plasma membrane] (Bos taurus)

IL4R [plasma membrane] (Canis familiaris)

IL4R [plasma membrane] (Gallus gallus)

IL4R [plasma membrane] (Sus scrofa)

il2rg [plasma membrane] (Xenopus tropicalis)

epor [plasma membrane] (Danio rerio)

Il4r [plasma membrane] (Mus musculus)

Il4r [plasma membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

1697

OpenTargets

ENSG00000077238

ENSEMBL

ENST00000543915, ENSP00000441667, ENSP00000379111, ENST00000395762, ENSG00000077238, ENST00000170630, ENSP00000170630

HPA

ENSG00000077238-IL4R

GeneCards

IL4R

PRO

P24394

Pharos - Targets

P24394

PDB

1IAR, 3BPL, 5E4E, 6WGL, 1IRS, 3BPN, 6OEL, 3BPO, 8K4Q

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05112 IL4	1	IL4 [extracellular region] (R-HSA-447110)	0.811	7
UniProt:P31785 IL2RG	4	IL2RG [plasma membrane] (R-HSA-449139) p-Y-IL2RG [plasma membrane] (R-HSA-6786103) p-Y-IL2RG [cytosol] (R-HSA-9009721) IL2RG [endosome] (R-HSA-8983165)	0.667	5
UniProt:P42226 STAT6	6	p-Y641-STAT6 [cytosol] (R-HSA-6786109) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) STAT6 [cytosol] (R-HSA-629625) p-S407-STAT6 [cytosol] (R-HSA-3249369) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241)	0.643	4
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.558	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.527	2
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.527	2
UniProt:Q86XL3 ANKLE2	2	Ac-K302-ANKLE2 [endoplasmic reticulum membrane] (R-HSA-9667946) ANKLE2 [endoplasmic reticulum membrane] (R-HSA-2529000)	0.527	2
UniProt:P29350 PTPN6	5	PTPN6 [cytosol] (R-HSA-197938) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641)	0.527	2
UniProt:P29597 TYK2	5	p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) TYK2 [cytosol] (R-HSA-877348) p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424)	0.527	2
UniProt:Q9Y397 ZDHHC9	1	ZDHHC9 [Golgi membrane] (R-HSA-9647931)	0.527	2
UniProt:Q9NYH9 UTP6	1	UTP6 [nucleoplasm] (R-HSA-6790674)	0.527	2
UniProt:Q96HE9 PRR11			0.527	2
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.527	2
UniProt:Q99640 PKMYT1	3	PKMYT1 [nucleoplasm] (R-HSA-74386) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [cytosol] (R-HSA-157457)	0.527	2
UniProt:Q969Z4 TR19L			0.527	2

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