Reactome | IL13RA2 [extracellular region]

IL13RA2 [extracellular region]

Stable Identifier

R-HSA-449666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IL13BP, Interleukin-13 receptor alpha-2, I13R2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1

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External Reference Information

External Reference

UniProt:Q14627 IL13RA2

Gene Names

IL13RA2, IL13R

Chain

signal peptide:1-26, chain:27-380

Reference Genes

BioGPS Gene:3598 IL13RA2

COSMIC (genes):IL13RA2 IL13RA2

CTD Gene:3598 IL13RA2

dbSNP Gene:3598 IL13RA2

ENSEMBL:ENSG00000123496 IL13RA2

ENSEMBL_homo_sapiens_GENE:ENSG00000123496.8 IL13RA2

HGNC:5975 IL13RA2

KEGG Gene (Homo sapiens):3598 IL13RA2

Monarch:3598 IL13RA2

NCBI Gene:3598 IL13RA2

OMIM:300130 IL13RA2

UCSC:Q14627 IL13RA2

Reference Transcript

RefSeq:NM_000640.2 IL13RA2

Other Identifiers

1016_s_at

11757033_a_at

17113448

206172_PM_at

206172_at

3598

4018735

4018736

4018737

4018738

4018739

4018740

4018741

4018742

4018743

4018744

4018745

4018746

4018747

4018748

8174598

A_23_P85209

GE60258

GO:0002376

GO:0002638

GO:0004896

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0009897

GO:0016020

GO:0016064

GO:0016192

GO:0019221

GO:0019955

GO:0023052

GO:0043235

GO:0043305

GO:0060089

HMNXSV003057936

ILMN_1688722

PH_hs_0023876

TC0X001290.hg

U70981_at

g10834991_3p_at

Participates

as a component of

IL13:IL13RA2 [extracellular region] (Homo sapiens)

as an input of

IL13 binds IL13RA2 (Homo sapiens)

Inferred To

IL13RA2 [extracellular region] (Bos taurus)

IL13RA2 [extracellular region] (Canis familiaris)

IL13RA2 [extracellular region] (Sus scrofa)

Il13ra2 [extracellular region] (Mus musculus)

Il13ra2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000631.1

Guide to Pharmacology - Targets

1701

OpenTargets

ENSG00000123496

GeneCards

Q14627

HPA

ENSG00000123496-IL13RA2

Ensembl

ENSG00000123496, ENSP00000361004, ENST00000243213, ENSP00000243213, ENST00000371936

PRO

Q14627

Pharos - Targets

Q14627

PDB

3LB6

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36222 CHI3L1	2	CHI3L1 [extracellular region] (R-HSA-6806319) CHI3L1 [specific granule lumen] (R-HSA-6799507)	0.804	9
UniProt:P35225 IL13	1	IL13 [extracellular region] (R-HSA-447211)	0.802	9
UniProt:Q86XT9 TMEM219	1	TMEM219 [plasma membrane] (R-HSA-6800018)	0.709	9
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q96CB8 INTS12	1	INTS12 [nucleoplasm] (R-HSA-6807456)	0.527	2
UniProt:O60512 B4GALT3	1	B4GALT3 [Golgi membrane] (R-HSA-975922)	0.527	2
UniProt:Q9H6X2 ANTXR1			0.527	2
UniProt:P33981 TTK			0.527	2
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.527	2
UniProt:Q8IUR0 TRAPPC5	1	TRAPPC5 [cytosol] (R-HSA-5683765)	0.527	2
UniProt:Q9BV35 SCMC3			0.527	2
UniProt:O14972 VP26C			0.527	2
UniProt:O95707 POP4	1	POP4 [nucleoplasm] (R-HSA-5696789)	0.527	2
UniProt:Q9BUJ0 ABHEA			0.527	2
UniProt:Q6NSJ2 PHLB3			0.527	2
UniProt:O60476 MAN1A2	2	MAN1A2 [transport vesicle] (R-HSA-8847486) MAN1A2 [Golgi membrane] (R-HSA-964747)	0.527	2
UniProt:Q16842 ST3GAL2	1	ST3GAL2 [Golgi membrane] (R-HSA-981482)	0.527	2
UniProt:Q9BZL6 PRKD2	1	PRKD2 [cytosol] (R-HSA-58214)	0.527	2
UniProt:P35453 HXD13			0.527	2
UniProt:Q02338 BDH1	1	BDH1 [mitochondrial matrix] (R-HSA-73922)	0.527	2
UniProt:Q63HK5 TSH3			0.527	2
UniProt:Q14680 MELK			0.527	2
UniProt:Q9ULE6 PALD			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q9HC98 NEK6	2	NEK6 [cytosol] (R-HSA-2530596) p-S206-NEK6 [cytosol] (R-HSA-2984253)	0.527	2
UniProt:Q8NE86 MCU	1	MCU [mitochondrial inner membrane] (R-HSA-8949184)	0.527	2
UniProt:Q92615 LAR4B			0.527	2
UniProt:Q9BZM4 ULBP3	1	ULBP3 [plasma membrane] (R-HSA-198076)	0.527	2
UniProt:Q9NWK9 BCD1			0.527	2
UniProt:Q9UBI1 COMMD3	4	COMMD3 [nucleoplasm] (R-HSA-8955108) COMMD3 [cytosol] (R-HSA-8955113) COMMD3 [extracellular region] (R-HSA-6806501) COMMD3 [ficolin-1-rich granule lumen] (R-HSA-6801405)	0.527	2
UniProt:Q92616 GCN1	1	GCN1 [cytosol] (R-HSA-9633010)	0.527	2
UniProt:Q9NUE0 ZDH18			0.527	2
UniProt:A6NJ78 MET15			0.527	2
UniProt:O75879 GATB			0.527	2
UniProt:O94919 ENDOD1	2	ENDOD1 [extracellular region] (R-HSA-8862988) ENDOD1 [cytosol] (R-HSA-8862967)	0.527	2
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.527	2
UniProt:Q15390 MTFR1			0.527	2
UniProt:Q8N442 GUF1			0.527	2
UniProt:Q05823 RNASEL	2	RNASEL [mitochondrial matrix] (R-HSA-5223312) RNASEL [cytosol] (R-HSA-1015684)	0.527	2
UniProt:P41273 TNFSF9	1	TNFSF9 [plasma membrane] (R-HSA-5667144)	0.527	3
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:Q5VYK3 ECM29			0.527	2
UniProt:Q86Y56 DAAF5			0.527	2
UniProt:Q9NWZ5 UCKL1	1	UCKL1 [cytosol] (R-HSA-8954322)	0.527	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.527	2
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.527	2
UniProt:Q14118 DAG1	10	GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GlcNAc,1,2-Man-DAG1 [Golgi lumen] (R-HSA-5617087) Man-DAG1 [Golgi lumen] (R-HSA-8931888) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(654-895) [plasma membrane] (R-HSA-2328154)	0.527	2
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.527	2
UniProt:Q9P244 LRFN1	1	SALM2 [plasma membrane] (R-HSA-204734)	0.527	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.527	2
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.527	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.527	2
UniProt:P50548 ERF	3	p-T526-ERF [nucleoplasm] (R-HSA-3209166) p-T526-ERF [cytosol] (R-HSA-3209167) ERF [nucleoplasm] (R-HSA-2534321)	0.527	2
UniProt:Q9UK39 NOCT	1	CCRN4L [nucleoplasm] (R-HSA-508391)	0.527	2
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.527	2
UniProt:Q6SPF0 SAMD1			0.527	2
UniProt:Q5T160 RARS2	1	RARS2 [mitochondrial matrix] (R-HSA-379589)	0.527	2
UniProt:P17931 LGALS3	3	LGALS3 [ficolin-1-rich granule membrane] (R-HSA-6803307) LGALS3 [secretory granule membrane] (R-HSA-6803327) LGALS3 [plasma membrane] (R-HSA-879445)	0.499	2
UniProt:P36222-PRO_0000011965 CHI3L1			0.463	2

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