The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.
Shanebeck, K, Anderson, DM, Ahdieh, M, Kumaki, S, Loomis, A, Park, LS, DuBose, R, Friend, DJ, Giri, JG, Cosman, D
Copeland, NG, Anderson, DM, Ahdieh, M, Kumaki, S, Jenkins, NA, Loomis, A, Tometsko, M, Bertles, J, Gilbert, DJ, Giri, J
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