Reactome | IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

Stable Identifier

R-HSA-449115

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

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The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.

Literature References

PubMed ID	Title	Journal	Year
7641685	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor Giri, JG, Kumaki, S, Ahdieh, M, Friend, DJ, Loomis, A, Shanebeck, K, DuBose, R, Cosman, D, Park, LS, Anderson, DM	EMBO J	1995
8530383	Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes Anderson, DM, Kumaki, S, Ahdieh, M, Bertles, J, Tometsko, M, Loomis, A, Giri, J, Copeland, NG, Gilbert, DJ, Jenkins, NA	J Biol Chem	1995