IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

Stable Identifier
R-HSA-449115
Type
Reaction [uncertain]
Species
Homo sapiens
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The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.

Literature References
PubMed ID Title Journal Year
8530383 Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes

Anderson, DM, Kumaki, S, Ahdieh, M, Bertles, J, Tometsko, M, Loomis, A, Giri, J, Copeland, NG, Gilbert, DJ, Jenkins, NA

J Biol Chem 1995
7641685 Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

Giri, JG, Kumaki, S, Ahdieh, M, Friend, DJ, Loomis, A, Shanebeck, K, DuBose, R, Cosman, D, Park, LS, Anderson, DM

EMBO J 1995
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