IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

Stable Identifier
Reaction [uncertain]
Homo sapiens
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The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.
Literature References
PubMed ID Title Journal Year
7641685 Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

Shanebeck, K, Anderson, DM, Ahdieh, M, Kumaki, S, Loomis, A, Park, LS, DuBose, R, Friend, DJ, Giri, JG, Cosman, D

EMBO J 1995
8530383 Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes

Copeland, NG, Anderson, DM, Ahdieh, M, Kumaki, S, Jenkins, NA, Loomis, A, Tometsko, M, Bertles, J, Gilbert, DJ, Giri, J

J Biol Chem 1995
Orthologous Events
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