CD4 is a receptor for Interleukin-16 (IL16), explaining how IL16 acts as a chemoattractant for a variety of CD4+ immune cells (Cruikshank et al. 2000, Cruikshank & Little 2008). Signaling mediated by CD4 requires the amino acid sequence W345 to S350, located in the proximal end of the D4 domain. CD4 does not appear to require a co-receptor for IL16. Data from CD4 knockout mice suggests that there may be an additional IL16 receptor (Mathy et al. 2000).
Center, DM, Ryan, TC, Collins, TL, Kornfeld, H, Cruikshank, WW
Center, DM, Liu, Y, O'Reilly, P, Kornfeld, H, O'Loughlin, T, Cruikshank, WW
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