CD4 binds Interleukin-16

Stable Identifier
R-HSA-449087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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CD4 binds Interleukin-16
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CD4 is a receptor for Interleukin-16 (IL16), explaining how IL16 acts as a chemoattractant for a variety of CD4+ immune cells (Cruikshank et al. 2000, Cruikshank & Little 2008). Signaling mediated by CD4 requires the amino acid sequence W345 to S350, located in the proximal end of the D4 domain. CD4 does not appear to require a co-receptor for IL16. Data from CD4 knockout mice suggests that there may be an additional IL16 receptor (Mathy et al. 2000).
Literature References
PubMed ID Title Journal Year
7615501 The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration

Ryan, TC, Cruikshank, WW, Kornfeld, H, Collins, TL, Center, DM

J Biol Chem 1995
10438516 Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation

Liu, Y, Cruikshank, WW, O'Loughlin, T, O'Reilly, P, Center, DM, Kornfeld, H

J Biol Chem 1999
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Orthologous Events
CD4 binds Interleukin-16 (Mus musculus)
CD4 binds Interleukin-16 (Rattus norvegicus)
CD4 binds Interleukin-16 (Sus scrofa)
CD4 binds Interleukin-16 (Xenopus tropicalis)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-27)
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