Reactome | CD4 binds Interleukin-16

CD4 binds Interleukin-16

Stable Identifier

R-HSA-449087

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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CD4 is a receptor for Interleukin-16 (IL16), explaining how IL16 acts as a chemoattractant for a variety of CD4+ immune cells (Cruikshank et al. 2000, Cruikshank & Little 2008). Signaling mediated by CD4 requires the amino acid sequence W345 to S350, located in the proximal end of the D4 domain. CD4 does not appear to require a co-receptor for IL16. Data from CD4 knockout mice suggests that there may be an additional IL16 receptor (Mathy et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
7615501	The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migration Center, DM, Ryan, TC, Collins, TL, Kornfeld, H, Cruikshank, WW	J Biol Chem	1995
10438516	Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation Center, DM, Liu, Y, O'Reilly, P, Kornfeld, H, O'Loughlin, T, Cruikshank, WW	J Biol Chem	1999