Interaction of MyoD:E protein with MEF2

Stable Identifier
R-HSA-448963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MyoD-E protein heterodimers interact with MEF2 proteins to synergistically activate myogenesis. This interaction occurs via association of these two heterologous classes of transcription factors through their DNA-binding and dimerization motifs. The combinatorial associations of these two protein families appear to establish a transcriptional code specific for skeletal muscle gene activation. Together with the Mef2 proteins and E proteins, MyoD transcription factors are responsible for coordinating muscle-specific gene expression in the undifferentiated myoblast. MyoD activation leads to expression of myogenin, M-cadherin, myosin heavy and light chains, and muscle creatine kinase.

Literature References
PubMed ID Title Journal Year
9418854 Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2

Black, BL, Molkentin, JD, Olson, EN

Mol Cell Biol 1998
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