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Interaction of MyoD:E protein with MEF2
Stable Identifier
R-HSA-448963
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Interaction of MyoD:E protein with MEF2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MyoD-E protein heterodimers interact with MEF2 proteins to synergistically activate myogenesis. This interaction occurs via association of these two heterologous classes of transcription factors through their DNA-binding and dimerization motifs. The combinatorial associations of these two protein families appear to establish a transcriptional code specific for skeletal muscle gene activation. Together with the Mef2 proteins and E proteins, MyoD transcription factors are responsible for coordinating muscle-specific gene expression in the undifferentiated myoblast. MyoD activation leads to expression of myogenin, M-cadherin, myosin heavy and light chains, and muscle creatine kinase.
Literature References
PubMed ID
Title
Journal
Year
9418854
Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2
Black, BL
,
Molkentin, JD
,
Olson, EN
Mol Cell Biol
1998
Participants
Input
Myod:phospho-E heterodimers [nucleoplasm]
(Homo sapiens)
phospho-MEF2 proteins [nucleoplasm]
(Homo sapiens)
Output
MyoD:phospho-E:phospho MEF2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Myogenesis (Homo sapiens)
Orthologous Events
Interaction of MyoD:E protein with MEF2 (Bos taurus)
Interaction of MyoD:E protein with MEF2 (Caenorhabditis elegans)
Interaction of MyoD:E protein with MEF2 (Canis familiaris)
Interaction of MyoD:E protein with MEF2 (Danio rerio)
Interaction of MyoD:E protein with MEF2 (Drosophila melanogaster)
Interaction of MyoD:E protein with MEF2 (Gallus gallus)
Interaction of MyoD:E protein with MEF2 (Mus musculus)
Interaction of MyoD:E protein with MEF2 (Rattus norvegicus)
Interaction of MyoD:E protein with MEF2 (Sus scrofa)
Authored
Garapati, P V (2008-08-11)
Reviewed
Krauss, RS (2010-02-09)
Created
Garapati, P V (2009-11-26)
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