Reactome | p-T312,T319-MEF2A [nucleoplasm]

p-T312,T319-MEF2A [nucleoplasm]

Stable Identifier

R-HSA-448834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho-MEF2A

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q02078 MEF2A

Gene Names

MEF2A, MEF2

Chain

chain:1-507

Reference Genes

BioGPS Gene:4205 MEF2A

COSMIC (genes):MEF2A MEF2A

CTD Gene:4205 MEF2A

dbSNP Gene:4205 MEF2A

ENSEMBL:ENSG00000068305 MEF2A

HGNC:6993 MEF2A

KEGG:hsa:4205 MEF2A

Monarch:4205 MEF2A

NCBI Gene:4205 MEF2A

OMIM:600660 MEF2A

UCSC:Q02078 MEF2A

Reference Transcript

Participates

as a member of

phospho-MEF2 proteins [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MEF2A [nucleoplasm]

p-S408-MEF2A [nucleoplasm]

Inferred To

phospho-MEF2A [nucleoplasm] (Sus scrofa)

phospho-Mef2 [nucleoplasm] (Drosophila melanogaster)

phospho-RLM1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-Mef2a [nucleoplasm] (Rattus norvegicus)

phospho-mef-2 [nucleoplasm] (Caenorhabditis elegans)

phospho-pvg4 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-mef2A [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-threonine at 312

Coordinate

312

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 319

Coordinate

319

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_054233926.1, XP_011519884.1, NP_001386990.1, XP_016877682.1, NP_001386969.1, NP_001386994.1, XP_016877679.1, NP_001352134.1, NP_001386965.1, XP_016877680.1, NP_001124399.1, NP_001352136.1, NP_001386979.1, NP_001306135.1, NP_005578.2, NP_001386964.1, XP_047288477.1, NP_001386960.1, NP_001352133.1, NP_001352137.1, XP_054233921.1, NP_001386987.1, XP_054233918.1, NP_001380488.1, NP_001386962.1, XP_054233916.1, NP_001339543.1, NP_001124398.1, NP_001386993.1, XP_047288486.1, XP_054233925.1, XP_054233927.1, NP_001386968.1, NP_001386989.1, NP_001386958.1, XP_047288480.1, NP_001386982.1, NP_001386980.1, NP_001386988.1, XP_054233917.1, XP_054233922.1, XP_047288485.1, XP_054233924.1, NP_001339546.1, NP_001386959.1, NP_001386992.1, NP_001165365.1, NP_001386967.1, XP_047288481.1, XP_047288487.1, NP_001352138.1, NP_001386961.1, NP_001386963.1, NP_001124400.1, NP_001386981.1, NP_001386985.1, NP_001386983.1, NP_001386991.1, NP_001339545.1, NP_001386995.1, XP_047288484.1, XP_011519883.1, XP_047288482.1, XP_016877683.1, NP_001386986.1, NP_001352132.1, XP_047288478.1, NP_001386978.1, NP_001386984.1, NP_001339544.1, XP_054233920.1, XP_011519888.1

OpenTargets

ENSG00000068305

ENSEMBL

ENSG00000068305, ENST00000449277, ENST00000691492, ENSP00000509137, ENST00000557785, ENSP00000509537, ENST00000686611, ENST00000557942, ENST00000558812, ENSP00000454120, ENSP00000453095, ENST00000354410, ENSP00000399460, ENSP00000346389, ENSP00000453441

HPA

ENSG00000068305-MEF2A

GeneCards

MEF2A

PRO

Q02078

Pharos - Targets

Q02078

GlyGen

Q02078

PDB

1LEW, 3MU6, 6BYY, 3KOV, 1C7U, 7XUZ, 1EGW, 3P57, 6BZ1

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14814 MEF2D	1	MEF2D [nucleoplasm] (R-HSA-445328)	0.527	3
UniProt:Q06413 MEF2C	3	MEF2C [nucleoplasm] (R-HSA-199938) p-S396-MEF2C [nucleoplasm] (R-HSA-199942) p-T293,T300,S387-MEF2C [nucleoplasm] (R-HSA-448838)	0.527	3
UniProt:P56524 HDAC4	3	HDAC4 [nucleoplasm] (R-HSA-351581) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029)	0.489	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	4

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