Reactome | IL19 binds IL20RA:JAK1:IL20RB

IL19 binds IL20RA:JAK1:IL20RB

Stable Identifier

R-HSA-448728

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

IL20RA:IL20RB binds IL19

ReviewStatus

5/5

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Interleukin-19 (IL19) binds a heterodimeric receptor complex that consists of Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-19 (IL19) (and Interleukin-20 (IL20) and Interleukin-24 (IL24)) (Gallagher et al. 2000, Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014, Pletnev et al. 2003).
This is a black box event because it is not clear whether the dimeric receptor can form in the absence of ligand.

Literature References

PubMed ID	Title	Journal	Year
22802649	Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines Logsdon, NJ, Rajashankar, KR, Harris, BD, Deshpande, A, Walter, MR	Proc. Natl. Acad. Sci. U.S.A.	2012
14580208	Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20 Pletnev, S, Kozlov, S, Tobin, G, Zdanov, A, Magracheva, E, Wlodawer, A, Kotenko, SV	Biochemistry	2003
12351624	Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions Madden, K, Chandrasekher, YA, Yao, L, Brandt, C, Foster, DC, Jelinek, L, Brender, T, McKernan, PA, Jaspers, S, West, J, Jones, C, Parrish-Novak, J, Xu, W	J Biol Chem	2002
11196675	Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10) Peat, JD, Gallagher, G, Vazquez, N, Dickensheets, H, Donnelly, RP, Pestka, S, Mirochnitchenko, OV, Kotenko, SV, Eskdale, J, Izotova, LS	Genes Immun.	2000