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CASP1(1-404) [cytosol]
Stable Identifier
R-HSA-448692
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Procaspase-1, CASP1 propeptide, Caspase-1 propeptide, CASP1, CASP1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
CTSG cleaves CASP1(1-404) (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
PYCARD recruits procaspase-1 via CARD (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
TP53 family members stimulate CASP1 expression (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
CTSG cleaves CASP1(1-404) (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The AIM2 inflammasome (Homo sapiens)
dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
The IPAF inflammasome (Homo sapiens)
IPAF binds procaspase-1 (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
PYCARD recruits procaspase-1 via CARD (Homo sapiens)
CASP1(1-404) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29466 CASP1
Gene Names
CASP1, IL1BC, IL1BCE
Chain
propeptide:1-119, chain:120-297, propeptide:298-316, chain:317-404
Reference Genes
BioGPS Gene:834 CASP1
COSMIC (genes):CASP1 CASP1
CTD Gene:834 CASP1
dbSNP Gene:834 CASP1
ENSEMBL:ENSG00000137752 CASP1
ENSEMBL_homo_sapiens_GENE:ENSG00000137752.25 CASP1
HGNC:1499 CASP1
KEGG Gene (Homo sapiens):834 CASP1
Monarch:834 CASP1
NCBI Gene:834 CASP1
OMIM:147678 CASP1
UCSC:P29466 CASP1
Reference Transcript
RefSeq:NM_001257119.2 CASP1
RefSeq:NM_033293.3 CASP1
RefSeq:NM_001223.4 CASP1
RefSeq:NM_033294.3 CASP1
RefSeq:NM_033292.3 CASP1
RefSeq:NM_001257118.2 CASP1
RefSeq:NM_033295.3 CASP1
Other Identifiers
11732870_a_at
11738884_x_at
11741076_a_at
11741885_x_at
11742386_a_at
11750552_s_at
11750553_x_at
11763186_at
1552703_PM_s_at
1552703_s_at
16743890
206011_PM_at
206011_at
209970_PM_x_at
209970_x_at
211366_PM_x_at
211366_x_at
211367_PM_s_at
211367_s_at
211368_PM_s_at
211368_s_at
3389354
3389355
3389356
3389357
3389358
3389359
3389360
3389361
3389364
3389365
3389366
3389367
3389369
3389370
3389371
3389372
3389373
3389375
3389399
3389409
3389458
3389459
3389464
39320_at
574_s_at
7951397
834
A_23_P202978
GE58945
GO:0002221
GO:0002376
GO:0003824
GO:0004175
GO:0004197
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006508
GO:0006915
GO:0006954
GO:0007165
GO:0007231
GO:0008233
GO:0008234
GO:0008656
GO:0012501
GO:0016020
GO:0016540
GO:0016787
GO:0019900
GO:0023052
GO:0032731
GO:0032741
GO:0032991
GO:0042742
GO:0042802
GO:0042981
GO:0043123
GO:0043226
GO:0043280
GO:0046456
GO:0050700
GO:0050727
GO:0050729
GO:0051604
GO:0051607
GO:0051716
GO:0061702
GO:0070269
GO:0071222
GO:0071260
GO:0071310
GO:0071346
GO:0072557
GO:0072558
GO:0072559
GO:0089720
GO:0097169
GO:0097179
GO:0098542
GO:0098772
GO:0140096
GO:0140447
GO:0140448
GO:0140970
GO:1903265
HMNXSV003029251
HMNXSV003046777
Hs.2490.0.S2_3p_at
Hs2.348365.1.S1_3p_s_at
ILMN_1727762
ILMN_2326509
ILMN_2326512
M87507_s_at
PH_hs_0000334
PH_hs_0029807
PH_hs_0030886
TC11003505.hg
g717041_3p_a_at
Participates
as an output of
TP53 family members stimulate CASP1 expression (Homo sapiens)
as an input of
CTSG cleaves CASP1(1-404) (Homo sapiens)
dsDNA:AIM2:ASC cluster binds procaspase-1 (Homo sapiens)
PYCARD recruits procaspase-1 via CARD (Homo sapiens)
IPAF binds procaspase-1 (Homo sapiens)
as a candidate of
Long prodomain caspases [cytosol] (Homo sapiens)
as a component of
dsDNA:AIM2 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
NLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1 [cytosol] (Homo sapiens)
IPAF elicitors:NLRC4:Procaspase-1 [cytosol] (Homo sapiens)
Other forms of this molecule
CASP1(1-119) [cytosol]
CASP1(120-297) [cytosol]
CASP1(317-404) [cytosol]
CASP1(298-316) [cytosol]
Inferred To
CASP1 [cytosol]
(Bos taurus)
CASP1 [cytosol]
(Sus scrofa)
Casp1 [cytosol]
(Mus musculus)
Casp1 [cytosol]
(Rattus norvegicus)
casp1 [cytosol]
(Xenopus tropicalis)
CASP4 [cytosol]
(Canis familiaris)
Cross References
RefSeq
NP_001244047.1
,
NP_001244048.1
,
NP_150635.1
,
NP_150634.1
,
NP_150637.1
,
NP_001214.1
,
NP_150636.1
ZINC - World Drugs
CASP1_HUMAN
Guide to Pharmacology - Targets
1617
OpenTargets
ENSG00000137752
ZINC - FDA approved
CASP1_HUMAN
ZINC - Substances
CASP1_HUMAN
ZINC - Biogenic
CASP1_HUMAN
ZINC target
P29466
PRO
P29466
PDB
1RWM
,
2HBY
,
5MTK
,
1ICE
,
2H48
,
6BZ9
,
2H54
,
1RWK
,
3E4C
,
3NS7
,
3D6M
,
6PZP
,
1RWP
,
1RWN
,
2HBZ
,
8WRA
,
6F6R
,
1IBC
,
1RWO
,
1RWV
,
1SC1
,
3D6F
,
1BMQ
,
2FQQ
,
6KN0
,
7KEU
,
1RWX
,
2H51
,
2H4Y
,
3D6H
,
1SC4
,
2HBR
,
5MMV
,
1RWW
,
6VIE
,
2H4W
,
1SC3
,
5FNA
,
2HBQ
ZINC - Investigational
CASP1_HUMAN
ZINC - Metabolites
CASP1_HUMAN
GeneCards
P29466
HPA
ENSG00000137752-CASP1
Ensembl
ENST00000525825
,
ENSP00000434779
,
ENSP00000433138
,
ENSP00000434303
,
ENST00000533400
,
ENST00000526568
,
ENSP00000434250
,
ENSP00000436875
,
ENST00000436863
,
ENST00000534497
,
ENSP00000410076
,
ENST00000531166
,
ENST00000695719
,
ENSG00000137752
,
ENSP00000512117
Pharos - Targets
P29466
ZINC - Predictions - Purchasable
CASP1_HUMAN
HMDB Protein
HMDBP02162
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.861
11
UniProt:Q9NPP4 NLRC4
1
NLRC4 [cytosol]
(R-HSA-561198)
0.743
4
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.666
4
UniProt:Q9C000 NLRP1
1
NLRP1 [cytosol]
(R-HSA-561196)
0.656
3
UniProt:P57730 CAR18
0.598
3
UniProt:Q5XLA6 CAR17
0.591
3
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.591
4
UniProt:P57764 GSDMD
13
GSDMD [specific granule lumen]
(R-HSA-6801468)
GSDMD [ficolin-1-rich granule lumen]
(R-HSA-6801498)
GSDMD [extracellular region]
(R-HSA-6801576)
GSDMD [tertiary granule lumen]
(R-HSA-6801501)
dithiocarb-C191-GSDMD(1-275) [cytosol]
(R-HSA-9693317)
GSDMD(88-484) [cytosol]
(R-HSA-9686133)
GSDMD(1-87) [cytosol]
(R-HSA-9686099)
GSDMD(1-275) [cytosol]
(R-HSA-9647641)
GSDMD [cytosol]
(R-HSA-6801577)
GSDMD(276-484) [cytosol]
(R-HSA-9647672)
S-(2-succinyl)-C191-GSDMD [cytosol]
(R-HSA-9716198)
GSDMD(269-484) [cytosol]
(R-HSA-9710116)
GSDMD(1-268) [cytosol]
(R-HSA-9710104)
0.591
4
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.587
2
UniProt:P58753-2 TIRAP
0.581
5
UniProt:P01583 IL1A
4
Myr82K-Myr83K-IL1A [extracellular region]
(R-HSA-445746)
IL1A(1-112) [cytosol]
(R-HSA-449059)
2xMyri-IL1A [cytosol]
(R-HSA-449054)
IL1A(1-271) [cytosol]
(R-HSA-449042)
0.524
3
UniProt:O14862 AIM2
1
AIM2 [cytosol]
(R-HSA-874111)
0.488
2
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