Reactome | CASP1(120-297) [cytosol]

CASP1(120-297) [cytosol]

Stable Identifier

R-HSA-448686

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP1, CASP1 p20, Caspase-1 subunit p20, CASP1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9ULZ3 PYCARD

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)
        
        CASP1(120-297) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29466 CASP1

Gene Names

CASP1, IL1BC, IL1BCE

Chain

propeptide:1-119, chain:120-297, propeptide:298-316, chain:317-404

Reference Genes

BioGPS Gene:834 CASP1

COSMIC (genes):CASP1 CASP1

CTD Gene:834 CASP1

dbSNP Gene:834 CASP1

ENSEMBL:ENSG00000137752 CASP1

ENSEMBL_homo_sapiens_GENE:ENSG00000137752.25 CASP1

HGNC:1499 CASP1

KEGG Gene (Homo sapiens):834 CASP1

Monarch:834 CASP1

NCBI Gene:834 CASP1

OMIM:147678 CASP1

UCSC:P29466 CASP1

Reference Transcript

Other Identifiers

11732870_a_at

11738884_x_at

11741076_a_at

11741885_x_at

11742386_a_at

11750552_s_at

11750553_x_at

11763186_at

1552703_PM_s_at

1552703_s_at

16743890

206011_PM_at

206011_at

209970_PM_x_at

209970_x_at

211366_PM_x_at

211366_x_at

211367_PM_s_at

211367_s_at

211368_PM_s_at

211368_s_at

3389354

3389355

3389356

3389357

3389358

3389359

3389360

3389361

3389364

3389365

3389366

3389367

3389369

3389370

3389371

3389372

3389373

3389375

3389399

3389409

3389458

3389459

3389464

39320_at

574_s_at

7951397

834

A_23_P202978

GE58945

GO:0002221

GO:0002376

GO:0003824

GO:0004175

GO:0004197

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006508

GO:0006915

GO:0006954

GO:0007165

GO:0007231

GO:0008233

GO:0008234

GO:0008656

GO:0012501

GO:0016020

GO:0016540

GO:0016787

GO:0019900

GO:0023052

GO:0032731

GO:0032741

GO:0032991

GO:0042742

GO:0042802

GO:0042981

GO:0043123

GO:0043226

GO:0043280

GO:0046456

GO:0050700

GO:0050727

GO:0050729

GO:0051604

GO:0051607

GO:0051716

GO:0061702

GO:0070269

GO:0071222

GO:0071260

GO:0071310

GO:0071346

GO:0072557

GO:0072558

GO:0072559

GO:0089720

GO:0097169

GO:0097179

GO:0098542

GO:0098772

GO:0140096

GO:0140447

GO:0140448

GO:0140970

GO:1903265

HMNXSV003029251

HMNXSV003046777

Hs.2490.0.S2_3p_at

Hs2.348365.1.S1_3p_s_at

ILMN_1727762

ILMN_2326509

ILMN_2326512

M87507_s_at

PH_hs_0000334

PH_hs_0029807

PH_hs_0030886

TC11003505.hg

g717041_3p_a_at

Participates

as a component of

CASP1(120-197):CASP1(317-404) [cytosol] (Homo sapiens)

as an input of

Formation of caspase-1 p10/p20 dimer (Homo sapiens)

as an output of

CTSG cleaves CASP1(1-404) (Homo sapiens)

Other forms of this molecule

CASP1(1-119) [cytosol]

CASP1(317-404) [cytosol]

CASP1(298-316) [cytosol]

CASP1(1-404) [cytosol]

Inferred To

CASP1 [cytosol] (Bos taurus)

CASP1 [cytosol] (Sus scrofa)

Casp1 [cytosol] (Mus musculus)

Casp1 [cytosol] (Rattus norvegicus)

casp1 [cytosol] (Xenopus tropicalis)

CASP4 [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_001244047.1, NP_001244048.1, NP_150635.1, NP_150634.1, NP_150637.1, NP_001214.1, NP_150636.1

ZINC - World Drugs

CASP1_HUMAN

Guide to Pharmacology - Targets

1617

OpenTargets

ENSG00000137752

ZINC - FDA approved

CASP1_HUMAN

ZINC - Substances

CASP1_HUMAN

ZINC - Biogenic

CASP1_HUMAN

ZINC target

P29466

PRO

P29466

PDB

1RWM, 2HBY, 5MTK, 1ICE, 2H48, 6BZ9, 2H54, 1RWK, 3E4C, 3NS7, 3D6M, 6PZP, 1RWP, 1RWN, 2HBZ, 8WRA, 6F6R, 1IBC, 1RWO, 1RWV, 1SC1, 3D6F, 1BMQ, 2FQQ, 6KN0, 7KEU, 1RWX, 2H51, 2H4Y, 3D6H, 1SC4, 2HBR, 5MMV, 1RWW, 6VIE, 2H4W, 1SC3, 5FNA, 2HBQ

ZINC - Investigational

CASP1_HUMAN

ZINC - Metabolites

CASP1_HUMAN

GeneCards

P29466

HPA

ENSG00000137752-CASP1

Ensembl

ENST00000525825, ENSP00000434779, ENSP00000433138, ENSP00000434303, ENST00000533400, ENST00000526568, ENSP00000434250, ENSP00000436875, ENST00000436863, ENST00000534497, ENSP00000410076, ENST00000531166, ENST00000695719, ENSG00000137752, ENSP00000512117

Pharos - Targets

P29466

ZINC - Predictions - Purchasable

CASP1_HUMAN

HMDB Protein

HMDBP02162

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [azurophil granule lumen] (R-HSA-6798768) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [secretory granule lumen] (R-HSA-6800957)	0.861	11
UniProt:Q9NPP4 NLRC4	1	NLRC4 [cytosol] (R-HSA-561198)	0.743	4
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.666	4
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.656	3
UniProt:P57730 CAR18			0.598	3
UniProt:Q5XLA6 CAR17			0.591	3
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.591	4
UniProt:P57764 GSDMD	13	GSDMD [specific granule lumen] (R-HSA-6801468) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [tertiary granule lumen] (R-HSA-6801501) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317) GSDMD(88-484) [cytosol] (R-HSA-9686133) GSDMD(1-87) [cytosol] (R-HSA-9686099) GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(276-484) [cytosol] (R-HSA-9647672) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104)	0.591	4
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.587	2
UniProt:P58753-2 TIRAP			0.581	5
UniProt:P01583 IL1A	4	Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) IL1A(1-271) [cytosol] (R-HSA-449042)	0.524	3
UniProt:O14862 AIM2	1	AIM2 [cytosol] (R-HSA-874111)	0.488	2