Reactome | OSMR [plasma membrane]

OSMR [plasma membrane]

Stable Identifier

R-HSA-448654

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Oncostatin-M specific receptor subunit beta, OSMR_HUMAN, OSMR beta

Locations in the PathwayBrowser for interactor UniProt:P23458 JAK1

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-6 family signaling (Homo sapiens)
      - IL-6-type cytokine receptor ligand interactions (Homo sapiens)
        
        JAKs bind OSMR (Homo sapiens)
        
        OSMR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99650 OSMR

Gene Names

OSMR, OSMRB

Chain

signal peptide:1-27, chain:28-979

Reference Genes

BioGPS Gene:9180 OSMR

COSMIC (genes):OSMR OSMR

CTD Gene:9180 OSMR

dbSNP Gene:9180 OSMR

ENSEMBL:ENSG00000145623 OSMR

ENSEMBL_homo_sapiens_GENE:ENSG00000145623.13 OSMR

HGNC:8507 OSMR

KEGG Gene (Homo sapiens):9180 OSMR

Monarch:9180 OSMR

NCBI Gene:9180 OSMR

OMIM:601743 OSMR

UCSC:Q99650 OSMR

Reference Transcript

Other Identifiers

11733184_a_at

11733185_at

11733186_at

11752556_a_at

11759644_at

1554008_PM_at

1554008_at

1648_at

16984244

205729_PM_at

205729_at

226621_PM_at

226621_at

2807375

2807376

2807377

2807382

2807383

2807389

2807390

2807391

2807394

2807396

2807397

2807398

2807399

2807401

2807403

2807404

2807408

2807409

2807411

2807412

2807414

2807415

2807417

2807418

2807423

2807425

2807426

2807427

2807428

2807429

2807430

2807431

39277_at

55640_at

8105040

84268_at

9180

A_14_P108529

A_14_P109264

A_14_P201364

A_21_P0000073

A_23_P156289

A_24_P145134

A_24_P388860

GE62862

GO:0002675

GO:0004896

GO:0004924

GO:0005127

GO:0005515

GO:0005886

GO:0005900

GO:0006954

GO:0008284

GO:0009897

GO:0016020

GO:0016324

GO:0019221

GO:0019838

GO:0019955

GO:0023052

GO:0034097

GO:0038165

GO:0043235

GO:0060089

HMNXSV003013386

HMNXSV003041232

HMNXSV003056290

Hs.75431.3.S1_3p_at

Hs2.238648.2.S1_3p_at

ILMN_2205999

PH_hs_0012877

TC05000179.hg

U60805_at

g4557039_3p_at

Participates

as a component of

as an input of

JAKs bind OSMR (Homo sapiens)

Inferred To

Osmr [plasma membrane] (Mus musculus)

Osmr [plasma membrane] (Rattus norvegicus)

lifra [plasma membrane] (Danio rerio)

osmr [plasma membrane] (Xenopus tropicalis)

OSMR [plasma membrane] (Canis familiaris)

OSMR [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_003990.1, NP_001310433.1, NP_001310434.1, NP_001161827.1, NP_001310435.1, NP_001310436.1

Guide to Pharmacology - Targets

1714

OpenTargets

ENSG00000145623

GeneCards

Q99650

HPA

ENSG00000145623-OSMR

Ensembl

ENSP00000274276, ENSG00000145623, ENSP00000422023, ENST00000502536, ENST00000274276

PRO

Q99650

Pharos - Targets

Q99650

Orphanet

16935

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23458 JAK1	6	p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335) JAK1 [endosome] (R-HSA-8983168) p-JAK1 [cytosol] (R-HSA-8950711) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921)	0.564	2
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P50458 LHX2	1	LHX2 [nucleoplasm] (R-HSA-9011100)	0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:P38646 HSPA9	6	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993)	0.499	4
UniProt:O75306 NDUFS2	1	NDUFS2 [mitochondrial matrix] (R-HSA-6788520)	0.499	4
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.499	4
UniProt:Q9UII2 ATIF1			0.463	4