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IL34 dimer [extracellular region]
Stable Identifier
R-HSA-448628
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1 dimer binds CSF1R or IL34 (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R dimerizes (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
IL34 dimer binds CSF1R (Homo sapiens)
CSF1R:IL34 dimer [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer binds PTPRZ1 (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer:PTPRZ1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer binds SDC1 (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer:SDC1 binds CSF1R (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer:SDC1:CSF1R [plasma membrane] (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimerizes (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
Participants
components
x 2
IL34 [extracellular region]
(Homo sapiens)
Participates
as a member of
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
as a component of
IL34 dimer:PTPRZ1 [plasma membrane] (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
CSF1R:IL34 dimer [plasma membrane] (Homo sapiens)
as an input of
IL34 dimer binds PTPRZ1 (Homo sapiens)
IL34 dimer binds SDC1 (Homo sapiens)
IL34 dimer binds CSF1R (Homo sapiens)
as an output of
IL34 dimerizes (Homo sapiens)
Inferred To
IL34 dimer [extracellular region]
(Bos taurus)
IL34 dimer [extracellular region]
(Canis familiaris)
IL34 dimer [extracellular region]
(Danio rerio)
IL34 dimer [extracellular region]
(Gallus gallus)
IL34 dimer [extracellular region]
(Mus musculus)
IL34 dimer [extracellular region]
(Rattus norvegicus)
IL34 dimer [extracellular region]
(Sus scrofa)
IL34 dimer [extracellular region]
(Xenopus tropicalis)
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