IL33:IL1RL1 binds IL1RAP-1

Stable Identifier
R-HSA-448603
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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IL33:IL1RL1 binds IL1RAP-1
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The Interleukin-33 (IL33):Interleukin-1 receptor-like 1 (IL1RL1, ST2) complex binds the membrane-associated form of Interleukin-1 receptor accessory protein (IL1RAP-1).

After IL33:IL1RL1 ligand binding, IL1RL1 undergoes a conformational change, which allows the recruitment of IL1RAP-1 (Lingel et al. 2009, Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
19836339 Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes

Fairbrother, WJ, Niebuhr, M, Wiesmann, C, Pan, B, Appleton, BA, Lingel, A, Weiss, TM, Bazan, JF

Structure 2009
Participants
Input
Output
Participates
as an event of
Orthologous Events
IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)
IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)
IL33:IL1RL1 binds IL1RAP-1 (Sus scrofa)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-25)
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