IL33:IL1RL1 binds IL1RAP-1

Stable Identifier
R-HSA-448603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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IL33:IL1RL1 binds IL1RAP-1
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The Interleukin-33 (IL33):Interleukin-1 receptor-like 1 (IL1RL1, ST2) complex binds the membrane-associated form of Interleukin-1 receptor accessory protein (IL1RAP-1).

After IL33:IL1RL1 ligand binding, IL1RL1 undergoes a conformational change, which allows the recruitment of IL1RAP-1 (Lingel et al. 2009, Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
19836339 Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes

Lingel, A, Weiss, TM, Niebuhr, M, Pan, B, Appleton, BA, Wiesmann, C, Bazan, JF, Fairbrother, WJ

Structure 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IL33:IL1RL1 binds IL1RAP-1 (Mus musculus)
IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-25)