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IFNLR1 [plasma membrane]
Stable Identifier
R-HSA-448592
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL28RA, Interleukin-28 receptor alpha chain, I28RA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)
IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
JAK1 binds IFNLR1 (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
Other interleukin signaling (Homo sapiens)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
IFNLR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IU57 IFNLR1
Gene Names
IFNLR1, IL28RA, LICR2
Chain
signal peptide:1-20, chain:21-520
Reference Genes
BioGPS Gene:163702 IFNLR1
COSMIC (genes):IFNLR1 IFNLR1
CTD Gene:163702 IFNLR1
dbSNP Gene:163702 IFNLR1
ENSEMBL:ENSG00000185436 IFNLR1
HGNC:18584 IFNLR1
KEGG:hsa:163702 IFNLR1
Monarch:163702 IFNLR1
NCBI Gene:163702 IFNLR1
OMIM:607404 IFNLR1
UCSC:Q8IU57 IFNLR1
Reference Transcript
RefSeq:NM_173064.2 IFNLR1
RefSeq:NM_170743.3 IFNLR1
RefSeq:NM_173065.2 IFNLR1
Other Identifiers
11730080_x_at
1555499_PM_a_at
1555499_a_at
163702
16683551
2401775
2401776
2401777
2401778
2401779
2401780
2401781
2401782
2401783
2401784
2401785
2401786
2401787
2401788
2401789
2401790
2401796
2401797
2401798
2401800
244261_PM_at
244261_at
75510_at
7913776
A_23_P74112
A_24_P19677
A_33_P3268612
GE563816
GO:0002376
GO:0002385
GO:0004896
GO:0005515
GO:0005886
GO:0008285
GO:0016020
GO:0019221
GO:0032002
GO:0034342
GO:0038196
GO:0050691
GO:0051607
GO:0060089
GO:0098542
GO:0098586
GO:1901857
HMNXSV003039289
Hs.105866.0.A1_3p_at
Hs2.386334.2.S1_3p_a_at
ILMN_1680805
ILMN_2405324
PH_hs_0018781
TC01002359.hg
Participates
as a component of
IFNLR1:p-JAK1 [plasma membrane] (Homo sapiens)
IFNLR1:JAK1 [plasma membrane] (Homo sapiens)
as an input of
JAK1 binds IFNLR1 (Homo sapiens)
Other forms of this molecule
p-Y343-Y517-IFNLR1 [plasma membrane]
Inferred To
ifnlr1 [plasma membrane]
(Danio rerio)
ifnlr1 [plasma membrane]
(Xenopus tropicalis)
ifngr2 [plasma membrane]
(Danio rerio)
ifnar2.2 [plasma membrane]
(Xenopus tropicalis)
crfb12 [plasma membrane]
(Danio rerio)
il22ra1 [plasma membrane]
(Xenopus tropicalis)
IFNLR1 [plasma membrane]
(Bos taurus)
IFNLR1 [plasma membrane]
(Canis familiaris)
IFNLR1 [plasma membrane]
(Gallus gallus)
IFNLR1 [plasma membrane]
(Sus scrofa)
crfb4 [plasma membrane]
(Danio rerio)
il22ra2 [plasma membrane]
(Danio rerio)
Homologues of IFNLR1 [plasma membrane]
(Danio rerio)
Homologues of IFNLR1 [plasma membrane]
(Xenopus tropicalis)
Ifnlr1 [plasma membrane]
(Mus musculus)
Ifnlr1 [plasma membrane]
(Rattus norvegicus)
il10ra [plasma membrane]
(Danio rerio)
il10ra [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_775088.1
,
NP_775087.1
,
NP_734464.1
Guide to Pharmacology - Targets
1733
ENSEMBL
ENSP00000327824
,
ENSP00000363539
,
ENSP00000328994
,
ENST00000374421
,
ENST00000327575
,
ENST00000327535
,
ENST00000374418
,
ENSP00000363542
OpenTargets
ENSG00000185436
HPA
ENSG00000185436-IFNLR1
PRO
Q8IU57
Pharos - Targets
Q8IU57
GlyGen
Q8IU57
PDB
5T5W
,
5IXD
,
3OG6
,
3OG4
,
5IXI
,
5L04
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:P09466 PAEP
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:Q4LDR2 CTXN3
0.556
3
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