Interleukin-32 binds proteinase-3

Stable Identifier
R-HSA-448591
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IL-32 has properties of a typical pro-inflammatory mediator, stimulating TNF-alpha, IL-1beta and IL-8 production, and activating the NF-kappaB and p38 mitogen-activated protein (MAP) kinase pathways. It is produced mainly by T, natural killer, epithelial and monocyte cells after stimulation by Interleukin-2, Interleukin-18 or IFN-gamma (Kim et al. 2005). IL-32 can bind proteinase 3, a neutrophil-derived serine protease, but its (assumed) receptor is unknown.

Literature References
PubMed ID Title Journal Year
16488976 Proteinase 3 is an IL-32 binding protein

Novick, D, Rubinstein, M, Azam, T, Rabinkov, A, Dinarello, CA, Kim, SH

Proc Natl Acad Sci U S A 2006
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