Reactome | IL22RA1 [plasma membrane]

IL22RA1 [plasma membrane]

Stable Identifier

R-HSA-448489

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-22 receptor subunit alpha-1, I22R1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8N6P7 IL22RA1

Gene Names

IL22RA1, IL22R

Chain

signal peptide:1-15, chain:16-574

Reference Genes

BioGPS Gene:58985 IL22RA1

COSMIC (genes):IL22RA1 IL22RA1

CTD Gene:58985 IL22RA1

dbSNP Gene:58985 IL22RA1

ENSEMBL:ENSG00000142677 IL22RA1

HGNC:13700 IL22RA1

Monarch:58985 IL22RA1

NCBI Gene:58985 IL22RA1

OMIM:605457 IL22RA1

UCSC:Q8N6P7 IL22RA1

Reference Transcript

RefSeq:NM_021258.3 IL22RA1

Other Identifiers

11752600_a_at

11755853_a_at

11763791_a_at

16683541

220056_PM_at

220056_at

2401755

2401756

2401757

2401758

2401759

2401760

2401761

2401764

2401765

2401766

2401767

2401768

2401770

2401771

58985

7913768

80910_r_at

A_24_P413479

GE82609

GO:0004896

GO:0004904

GO:0005515

GO:0005886

GO:0008150

GO:0019221

GO:0042015

GO:0042018

GO:0050728

GO:0050829

GO:0060089

GO:0098542

GO:0140865

HMNXSV003010487

ILMN_1666175

PH_hs_0006102

TC01002358.hg

TC01005333.hg

g10864066_3p_at

Participates

as an input of

IL22RA1 binds JAK1 (Homo sapiens)

as a component of

Other forms of this molecule

p-Y-251,p-Y301-IL22RA1 [plasma membrane]

Inferred To

ifnlr1 [plasma membrane] (Danio rerio)

ifnlr1 [plasma membrane] (Xenopus tropicalis)

Il22ra1 [plasma membrane] (Mus musculus)

Il22ra1 [plasma membrane] (Rattus norvegicus)

ifngr2 [plasma membrane] (Danio rerio)

Homologues of IL22RA1 [plasma membrane] (Danio rerio)

Homologues of IL22RA1 [plasma membrane] (Xenopus tropicalis)

ifnar2.2 [plasma membrane] (Xenopus tropicalis)

crfb12 [plasma membrane] (Danio rerio)

il22ra1 [plasma membrane] (Xenopus tropicalis)

IL22RA1 [plasma membrane] (Bos taurus)

IL22RA1 [plasma membrane] (Canis familiaris)

IL22RA1 [plasma membrane] (Gallus gallus)

IL22RA1 [plasma membrane] (Sus scrofa)

crfb4 [plasma membrane] (Danio rerio)

il22ra2 [plasma membrane] (Danio rerio)

il10ra [plasma membrane] (Danio rerio)

il10ra [plasma membrane] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

1731

ENSEMBL

ENST00000270800, ENSP00000270800

OpenTargets

ENSG00000142677

HPA

ENSG00000142677-IL22RA1

PRO

Q8N6P7

Pharos - Targets

Q8N6P7

GlyGen

Q8N6P7

PDB

3DLQ, 3DGC, 6DF3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZX6 IL22	1	IL22 [extracellular region] (R-HSA-448460)	0.852	9
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.547	2

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