IL22 binds IL22RA1:JAK1 receptor complex

Stable Identifier
Reaction [binding]
Homo sapiens
IL22RA1 binds IL22
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Temporal models suggest that the first event in IL22 receptor formation is binding of Interleukin-22 (IL22) to IL22RA1), which pre associates with JAK1 (Li et al. 2004, Jones et al. 2008, Xie et al. 2000, Xu et al. 2001).
The Interleukin-22 receptor consists of IL22RA1 and Interleukin-10 receptor subunit beta (IL10RB), which is also a component of the receptors for Interleukin-10 (IL10), Interleukin-22 (IL22), Interleukin-26 (IL26), Interleukin-28 (IL28), and Interferon lambda-1 (IFNL1).

Literature References
PubMed ID Title Journal Year
18599299 Structure of IL-22 bound to its high-affinity IL-22R1 chain

Jones, BC, Logsdon, NJ, Walter, MR

Structure 2008
11481447 A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

Chandrasekher, Y, Chen, Z, Madden, K, Maurer, M, Yao, L, Gao, Z, Kindsvogel, W, Dillon, SR, Gilbert, T, Storey, H, Foster, DC, Jelinek, L, Whitmore, TE, Brender, T, Grant, FJ, Presnell, SR, Jaspers, S, Hammond, A, Parrish-Novak, J, Schlutsmeyer, S, Topouzis, S, Xu, W, Clegg, CH

Proc Natl Acad Sci U S A 2001
10875937 Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

Goddard, AD, Stinson, J, Ho, WH, Xie, MH, Gurney, AL, Wood, WI, Aggarwal, S, Zhang, Z, Foster, J

J Biol Chem 2000
15120653 Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2

Crawford, TK, Wolfman, NM, Heveron, K, Tomkinson, KN, Spaulding, V, Ling, V, Tan, XY, Jacobs, KA, Deng, B, Wright, JF, Pittman, DD, Annis-Freeman, B, Wu, P, Li, J, Veldman, GM, De Zutter, G, Zollner, R, Yan, G, Fouser, LA, Liu, W

Int. Immunopharmacol. 2004
This event is regulated
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