Reactome | IL23R [plasma membrane]

IL23R [plasma membrane]

Stable Identifier

R-HSA-447156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-23 receptor component, IL23R_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5VWK5 IL23R

Gene Names

IL23R

Chain

signal peptide:1-23, chain:24-629

Reference Genes

BioGPS Gene:149233 IL23R

COSMIC (genes):IL23R IL23R

CTD Gene:149233 IL23R

dbSNP Gene:149233 IL23R

ENSEMBL:ENSG00000162594 IL23R

ENSEMBL_homo_sapiens_GENE:ENSG00000162594.17 IL23R

HGNC:19100 IL23R

KEGG Gene (Homo sapiens):149233 IL23R

Monarch:149233 IL23R

NCBI Gene:149233 IL23R

OMIM:607562 IL23R

UCSC:Q5VWK5 IL23R

Reference Transcript

Other Identifiers

11737362_x_at

11748794_a_at

149233

1552912_3p_a_at

1552912_PM_a_at

1552912_a_at

1561853_PM_a_at

1561853_a_at

16665878

2340933

2340934

2340935

2340936

2340939

2340941

2340943

2340944

2340947

2340948

2340951

2340952

2340953

2340954

2340955

2340956

2340957

2340958

7902189

A_14_P135991

A_23_P425197

GO:0001916

GO:0002230

GO:0002376

GO:0002827

GO:0004896

GO:0005143

GO:0005515

GO:0005886

GO:0006954

GO:0007155

GO:0009897

GO:0010536

GO:0016020

GO:0019221

GO:0019955

GO:0023052

GO:0030154

GO:0032496

GO:0032693

GO:0032725

GO:0032729

GO:0032735

GO:0032740

GO:0032819

GO:0034341

GO:0036211

GO:0038155

GO:0042019

GO:0042020

GO:0042102

GO:0042104

GO:0042509

GO:0042531

GO:0043235

GO:0043382

GO:0045087

GO:0045672

GO:0048856

GO:0050829

GO:0051135

GO:0060089

GO:0072536

GO:0098542

GO:2000318

GO:2000330

HMNXSV003000736

Hs2.375184.3.S1_3p_a_at

ILMN_1734937

ILMN_2223663

PH_hs_0018226

TC01000739.hg

TC01004453.hg

Participates

as an input of

IL23R binds JAK2 (Homo sapiens)

as a component of

as a member of

STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y-IL23R [plasma membrane]

Inferred To

IL23R [plasma membrane] (Bos taurus)

IL23R [plasma membrane] (Canis familiaris)

IL23R [plasma membrane] (Sus scrofa)

Il23r [plasma membrane] (Mus musculus)

Il23r [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_011539092.1, XP_005270573.1, XP_011539093.1, NP_653302.2

Guide to Pharmacology - Targets

1717

OpenTargets

ENSG00000162594

GeneCards

Q5VWK5

HPA

ENSG00000162594-IL23R

Ensembl

ENSG00000162594, ENSP00000513140, ENST00000697223, ENSP00000513191, ENST00000425614, ENST00000697153, ENSP00000513190, ENST00000697149, ENST00000697224, ENST00000347310, ENSP00000321345, ENSP00000513139, ENSP00000513138, ENST00000697150, ENSP00000387640, ENST00000697151, ENSP00000513142

PRO

Q5VWK5

Pharos - Targets

Q5VWK5

Orphanet

16256

PDB

6WDQ, 8OE4, 5MZV

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-9992716 INTERLEUKIN-23			0.558	2
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.556	3
UniProt:Q9NPF7 IL23A	2	IL23A [endoplasmic reticulum lumen] (R-HSA-8950224) IL23A [extracellular region] (R-HSA-447245)	0.525	2
UniProt:Q62120 Jak2	11	phospho-p-Y1007,Y1008-JAK2 [cytosol] (R-MMU-9005327) p-Jak2 [cytosol] (R-MMU-8950633) phospho-p-JAK2 [cytosol] (R-MMU-210621) phospho-p-Y813-JAK2 [cytosol] (R-MMU-997248) JAK2 [endosome lumen] (R-MMU-2002372) JAK2 [cytosol] (R-MMU-210620) phospho-p-Y1007-JAK2 [cytosol] (R-MMU-873799) Jak2 [cytosol] (R-MMU-205743) phospho-p-12Y-JAK2 [cytosol] (R-MMU-2586516) p-Y1007-Jak2 [cytosol] (R-MMU-997296) p-12Y-Jak2 [cytosol] (R-MMU-2586515)	0.499	2